Int Neurourol J > Volume 23(1); 2019 > Article |
|
Variable | OAB-wet (n=127) | OAB-dry (n=496) | P-valuea) | Coefficient or OR (95% CI) of OAB-wetb) | P-valueb) |
---|---|---|---|---|---|
Age (yr) | 61.8±13.4 | 55.3±13.0 | <0.001 | - | - |
Parity | 3.0±1.8 | 2.6±1.6 | 0.005 | - | - |
Qmax (mL/sec) | 20.9±11.3 | 19.2±8.5 | 0.38 | 2.00 (0.18–3.81) | 0.03 |
Voided volume (mL) | 245±129 | 281±119 | 0.004 | -25.2 (-49.0 to -1.4) | 0.04 |
Postvoid residual (mL) | 77±64 | 70±59 | 0.08 | 5.4 (-6.6 to 17.4) | 0.38 |
Voiding time (sec) | 54.8±78.0 | 56.2±52.2 | 0.001 | 0.24 (-22.5 to 11.8) | 0.98 |
Strong desire to void (mL) | 233±102 | 242±70 | 0.04 | -5.0 (-20.5 to 10.5) | 0.53 |
PdetQmax (cm H2O) | 35.6±21.9 | 31.3±19.0 | 0.04 | 6.0 (1.9–10.1) | 0.004 |
MUCP (cm H2O) | 63.3±29.5 | 73.3±32.2 | 0.002 | -2.0 (-7.5 to 3.4) | 0.47 |
Functional profile length (cm) | 3.1±0.8 | 3.1±0.9 | 0.98 | -0.01 (-0.18 to 0.17) | 0.95 |
PTR at MUP (%) | 89.8±29.8 | 95.4±31.4 | 0.08 | -5.1 (-11.4 to 1.1) | 0.11 |
Detrusor overactivity | 44 (35) | 129 (26) | 0.053 | 1.4 (0.9–2.2) | 0.12 |
Bladder oversensitivity | 101 (80) | 387 (78) | 0.71 | 1.0 (0.6–1.7) | 0.93 |
Urodynamic stress incontinence | 69 (54) | 165 (33) | <0.001 | 2.1 (1.4–3.1) | 0.001 |
Functional BOOc) | 25 (22) | 91 (21) | 0.95 | 1.06 (0.64–1.79) | 0.80 |
Pad weight (g) | 16.8±30.7 | 3.7±14.9 | <0.001 | 11.7 (7.9–15.5) | <0.001 |
BOOI | -6.6±2.7 | -8.2±1.3 | 0.69 | 2.5 (-3.2 to 8.2) | 0.38 |
Bladder contractility index | 141.2±63.4 | 129.8±46.7 | 0.21 | 14.8 (4.1–25.4) | 0.007 |
Values are expressed as the mean±standard deviation or number (%) unless otherwise indicated.
OAB, overactive bladder syndrome; OR, odds ratio; CI, confidence interval; Qmax, maximal flow rate; PdetQmax, detrusor pressure at maximal flow during voiding cystometry; MUCP, maximal urethral closure pressure; PTR, pressure transmission ratio; MUP, maximal urethral pressure; BOO, bladder outlet obstruction; BOOI, bladder outlet obstruction index.
b) Age and parity were significantly different between the OAB-wet and OAB-dry groups. The coefficient or odds ratio of OAB-wet (OAB-wet=1; OAB-dry=0) is derived from linear or logistic regression analysis of the value in each variable adjusted for age and parity to reveal the impact of OAB-wet on each variable, compared with OAB-dry.
Variable | OAB-wet (n=127) | OAB-dry (n=496) | P-valuea) | Coefficient (95% CI) of OAB-wetb) | P-valueb) |
---|---|---|---|---|---|
DVVmax (72 hr) | 359±161 | 356±166 | 0.68 | 5.8 (-26.8 to 38.3) | 0.73 |
Urgency episodes (72 hr) | 11.5±11.1 | 7.2±11.8 | <0.001 | 4.6 (2.3–6.9) | <0.001 |
Incontinence episodes (72 hr) | 6.4±7.0 | 0±0 | <0.001 | 6.3 (5.7–6.9) | <0.001 |
Daytime frequency (72 hr) | 29.1±10.6 | 31.5±16.3 | 0.39 | -1.2 (-4.2 to 1.8) | 0.42 |
Nocturia (72 hr) | 4.6±4.4 | 4.7±4.0 | 0.38 | -0.3 (-1.1 to 0.5) | 0.49 |
Total voided volume (mL/72 hr) | 5,490±2,478 | 5,487±2,067 | 0.51 | 51.3 (-378.4 to 481.1) | 0.82 |
Total water intake (mL/72 hr) | 4,845±2,063 | 5,039±1,984 | 0.29 | -105.8 (-502.7 to 291.10) | 0.60 |
Variable |
Univariate |
Multivariatea), model 1 |
Multivariatea), model 2 |
|||
---|---|---|---|---|---|---|
Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-valuea) | Odds ratio (95% CI) | P-valuea) | |
Age | 1.04 (1.02–1.060) | <0.001 | 1.05 (1.03–1.08) | <0.001 | 1.05 (1.03–1.08) | <0.001 |
Parity | 1.02 (1.06–1.34) | 0.004 | 0.92 (0.77–1.10) | 0.36 | 0.92 (0.77–1.10) | 0.37 |
Qmax | 1.02 (1.00–1.04) | 0.07 | 1.06 (1.03–1.09) | <0.001 | - | - |
Voided volume | 0.997 (0.996–0.999) | 0.003 | 0.996 (0.993–0.998) | 0.001 | 0.995 (0.993–0.998) | <0.001 |
PdetQmax | 1.01 (1.00–1.02) | 0.04 | 1.02 (1.01–1.03) | 0.003 | - | - |
Urodynamic stress incontinence | 2.39 (1.61–3.55) | <0.001 | 1.78 (1.13–2.82) | 0.01 | 1.75 (1.11–1.05) | 0.02 |
Urgency episodes | 1.03 (1.01–1.04) | <0.001 | 1.04 (1.02–1.05) | <0.001 | 1.04 (1.02–1.05) | <0.001 |
Bladder contractility indexb) | 1.004 (1.000–1.008) | 0.04 | - | - | 1.012 (1.007–1.018) | <0.001 |
Model 1: Using age, parity, and the other statistically significant adjusted variables shown in Tables 1 and 2, but not using bladder contractility index as a variable, a multivariable logistic regression was performed to predict OAB-wet; model 2: Bladder contractility index was included as a variable for multivariable logistic regression to predict OAB-wet, instead of using Qmax and PdetQmax as variables.
OAB, overactive bladder syndrome; CI, confidence interval; Qmax, maximal flow rate; PdetQmax, detrusor pressure at maximal flow during voiding cystometry.
a) Multivariate logistic regression was performed using the significant variables in Tables 1 and 2. However, we excluded the variable of incontinence episodes in the model because incontinence episodes >0 predicts OAB-wet perfectly, and women with incontinence episodes >0 were defined to be in the OAB-wet group.