The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases

  

Methylmercury induces inflammatory response and autophagy in microglia through the activation of NLRP3 inflammasome

Xinyue Li, Kai Ma, Tiantian Tian, Huan Pang, Tianxiang Liu, Meng Li, Jiali Li, Zhixuan Luo, Huiyuan Hu, Shanshan Hou, Jing Yu, Qiaohong Hou, Xiuling Song, Chao Zhao, Haiying Du, Jinhua Li, Zhongjun Du, Minghua Jin

Environment International.2024; 186: 108631.     CrossRef

Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space

Tae-Geun Yu, Jeong Seok Cha, Gijeong Kim, Yoo-Kyoung Sohn, Youngki Yoo, Uijin Kim, Ji-Joon Song, Hyun-Soo Cho, Hak-Sung Kim

Cell Death Discovery.2023;[Epub]     CrossRef

The Role and Mechanism of Metformin in Inflammatory Diseases

Huan Lin, Haiyong Ao, Guanghua Guo, Mingzhuo Liu

Journal of Inflammation Research.2023; Volume 16: 5545.     CrossRef

Elaidic acid induced NLRP3 inflammasome activation via ERS-MAPK signaling pathways in Kupffer cells

Hui Liu, Bo Nan, Chaoyue Yang, Xuenan Li, Haiyang Yan, Yuan Yuan

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022; 1867(1): 159061.     CrossRef

A Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease

Zhifeng Liu, Yi Jiao, Tianyuan Yu, Hourong Wang, Yingqi Zhang, Di Liu, Yajing Xu, Qian Guan, Mengqian Lu, Ying Li

Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef

Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease

Cheng-Hung Li, Chia-Lin Lee, Yu-Cheng Hsieh, Cheng-Hsu Chen, Ming-Ju Wu, Shang-Feng Tsai

BMC Nephrology.2022;[Epub]     CrossRef

rs3806265 and rs4612666 of the NLRP3 Gene Are Associated With the Titer of Glutamic Acid Decarboxylase Antibody in Type 1 Diabetes

Xiaoxiao Sun, Linling Xu, Ying Xia, Shuoming Luo, Jian Lin, Yang Xiao, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou

Frontiers in Endocrinology.2022;[Epub]     CrossRef

The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis

Jiwen Fan, Meng Ren, Binay Kumar Adhikari, Haodong Wang, Yuquan He

Journal of Inflammation Research.2022; Volume 15: 3847.     CrossRef

Inflammatory diseases in hematology: a review

Ryan Henrie, Hannah Cherniawsky, Krista Marcon, Eric J. Zhao, Angelina Marinkovic, Persia Pourshahnazari, Stephen Parkin, Luke Y. C. Chen

American Journal of Physiology-Cell Physiology.2022; 323(4): C1121.     CrossRef

An integrated analysis of C5AR2 related to malignant properties and immune infiltration of gliomas

Chengying Huang, Ouwen Qiu, Chaofu Mao, Zhicheng Hu, Shanqiang Qu

Cancer Innovation.2022; 1(3): 240.     CrossRef

Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5

Lili Deng, Mingyue Ma, Shuying Li, Lin Zhou, Sun Ye, Juan Wang, Qiaoqiao Yang, Chunling Xiao

Ecotoxicology and Environmental Safety.2022; 248: 114329.     CrossRef

Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro

Clinical Science.2021; 135(5): 687.     CrossRef

Sporotrichosis: Review of Innate and Acquired Immune Mechanisms

Andres Tirado-Sanchez, Alexandro Bonifaz

Journal of Skin and Stem Cell.2021;[Epub]     CrossRef

Association of nod-like receptor pyrin domain containing 3 (rs10754558) and protein kinase C zeta (rs2503706) gene polymorphisms with the risk of type 2 diabetes mellitus in Indian population

Kiran Bala, Vikas Kumar, Jaswinder Singh, Jasbir Singh

Gene Reports.2021; 23: 101093.     CrossRef

Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance

Xiaoqing Zhang, Huiyan Qu, Tao Yang, Xiaoni Kong, Hua Zhou

Biomedicine & Pharmacotherapy.2021; 143: 112219.     CrossRef

Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1β Release during a Uropathogenic Escherichia coli Infection In Vitro

Ashok Kumar Kumawat, Geena Varghese Paramel, Kartheyaene Jayaprakash Demirel, Isak Demirel

Cells.2021; 10(12): 3522.     CrossRef

COVID-19 and the Differences in Physiological Background Between Children and Adults and Their Clinical Consequences

L KAPUSTOVA, O PETROVICOVA, P BANOVCIN, M ANTOSOVA, A BOBCAKOVA, I URBANCIKOVA, Z RENNEROVA, M JESENAK

Physiological Research.2021; : S209.     CrossRef

Inflammation—The role of ATP in pre‐eclampsia

Paul Fodor, Benjamin White, Raheela Khan

Microcirculation.2020;[Epub]     CrossRef

Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis

Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Gao

Free Radical Biology and Medicine.2020; 146: 198.     CrossRef

Functional crosstalk between non‐canonical caspase‐11 and canonical NLRP3 inflammasomes during infection‐mediated inflammation

Young‐Su Yi

Immunology.2020; 159(2): 142.     CrossRef

RETRACTED ARTICLE: Laquinimod inhibits MMP+ induced NLRP3 inflammasome activation in human neuronal cells

Xue Zhang, Jianing Jin, Anmu Xie

Immunopharmacology and Immunotoxicology.2020; 42(3): 264.     CrossRef

NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: Effect of resveratrol and metformin

Ramesh Chandra Rai, Pankaj K. Bagul, Sanjay Kumar Banerjee

Life Sciences.2020; 253: 117727.     CrossRef

Effects of irbesartan on myocardial injury in diabetic rats: The role of NLRP3/ASC/Caspase-1 pathway

Li Rong, Shuo Sun, Feiyu Zhu, Qingmei Xu, Hui Li, Qin Gao, Wei Zhang, Bi Tang, Heng Zhang, Hongju Wang, Pinfang Kang

Journal of the Renin-Angiotensin-Aldosterone System.2020; 21(2): 147032032092604.     CrossRef

New variants in NLRP3 inflammasome genes increase risk for asthma and Blomia tropicalis-induced allergy in a Brazilian population

Gerson de A. Queiroz, Raimon R. da Silva, Anaque de O. Pires, Ryan dos S. Costa, Neuza M. Alcântara-Neves, Thiago M. da Silva, Mauricio L. Barreto, Sergio C. Oliveira, Camila A. Figueirêdo

Cytokine: X.2020; 2(3): 100032.     CrossRef

Biomedical nanomaterials for immunological applications: ongoing research and clinical trials

Vincent Lenders, Xanthippi Koutsoumpou, Ara Sargsian, Bella B. Manshian

Nanoscale Advances.2020; 2(11): 5046.     CrossRef

Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL‐1β secretion in murine macrophages

Priscila Carneiro Campos, Marco Túlio Ribeiro Gomes, Fábio Antônio Vitarelli Marinho, Erika Sousa Guimarães, Mariza Gabriela Faleiro de Moura Lodi Cruz, Sergio Costa Oliveira

European Journal of Immunology.2019; 49(7): 1023.     CrossRef

Serum Urate, Uricase, and Blood Pressure Control in Gout

Claudio Borghi, Agostino Virdis

Hypertension.2019; 74(1): 23.     CrossRef

Associations of a NLRP3 rs10754558 Polymorphism with Helicobacter pylori-Infected Patients with Gastritis and Peptic Ulcer Disease

Mahdieh Abolfathi, Nader Bagheri, Sara Iranparast, Amin Soltani, Ahmad Sanaei, Ghorbanali Rahimian, Soleyman Kheyri, Hedayatollah Shirzad

Jundishapur Journal of Microbiology.2019;[Epub]     CrossRef

Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent

Berhane Asfaw Idosa, Anne Kelly, Susanne Jacobsson, Isak Demirel, Hans Fredlund, Eva Särndahl, Alexander Persson

Journal of Immunology Research.2019; 2019: 1.     CrossRef

Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis

Ma Fangxiao, Ke Yifan, Zhong Jihong, Shen Yan, Liu Yingchao

Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef

NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy

Yan‑Zi Zhang, Xiao‑Lu Sui, Yun‑Peng Xu, Feng‑Juan Gu, Ai‑Sha Zhang, Ji‑Hong Chen

International Journal of Molecular Medicine.2019;[Epub]     CrossRef

Role of autophagy in LPS‑induced inflammation in INS‑1 cells

Li‑Bo Zhu, Ming‑Ming Cao, Jun Wang, Ying Su, Wei Jiang, Guo‑Dong Liu, Yan‑Bo Li

Molecular Medicine Reports.2019;[Epub]     CrossRef

Interaction between autophagy and the NLRP3 inflammasome

Zhenrui Cao, Yanhao Wang, Zhimin Long, Guiqiong He

Acta Biochimica et Biophysica Sinica.2019; 51(11): 1087.     CrossRef

Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells

Isak Demirel, Alexander Persson, Annelie Brauner, Eva Särndahl, Robert Kruse, Katarina Persson

Frontiers in Cellular and Infection Microbiology.2018;[Epub]     CrossRef

The roles of odontoblasts in dental pulp innate immunity

Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo

Japanese Dental Science Review.2018; 54(3): 105.     CrossRef

Study on the expressions of NLRP3 gene transcript variants in peripheral blood monocytes of primary gout patients

Wantai Dang, Dan Xu, Wenguang Xie, Jingguo Zhou

Clinical Rheumatology.2018; 37(9): 2547.     CrossRef

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants

Priscila Rezeck Nunes, Maria Terezinha Serrao Peracoli, Mariana Romao-Veiga, Mariana Leticia Matias, Vanessa Rocha Ribeiro, Celio Junior Da Costa Fernandes, Jose Carlos Peracoli, Jose Ricardo Rodrigues, Leandro De Oliveira

Pregnancy Hypertension.2018; 14: 29.     CrossRef

Related Research on NLRP3 Inflammasome and SLE

嘉妮 王

Advances in Clinical Medicine.2018; 08(06): 544.     CrossRef

Linarin prevents LPS‑induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF‑κB pathways

Xiang Han, Yi‑Chen Wu, Min Meng, Qing‑Song Sun, Su‑Min Gao, Hong Sun

International Journal of Molecular Medicine.2018;[Epub]     CrossRef

Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis

Shi Tang, Chenlin Gao, Yang Long, Wei Huang, Jiao Chen, Fang Fan, Chunxia Jiang, Yong Xu

Mediators of Inflammation.2017; 2017: 1.     CrossRef

Inflammation and Regeneration in the Dentin-pulp Complex: Net Gain or Net Loss?

Paul R. Cooper, Ilaria J. Chicca, Michael J. Holder, Michael R. Milward

Journal of Endodontics.2017; 43(9): S87.     CrossRef

ATP Induces IL-1βSecretion inNeisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis

Killen García, Gisselle Escobar, Pablo Mendoza, Caroll Beltran, Claudio Perez, Sergio Arancibia, Rolando Vernal, Paula I. Rodas, Claudio Acuña-Castillo, Alejandro Escobar

Mediators of Inflammation.2016; 2016: 1.     CrossRef

Association between functional NLRP3 polymorphisms and susceptibility to autoimmune and inflammatory diseases: a meta-analysis

Y H Lee, S-C Bae

Lupus.2016; 25(14): 1558.     CrossRef

Muramyl dipeptide activates human beta defensin 2 and pro-inflammatory mediators through Toll-like receptors and NLRP3 inflammasomes in human dental pulp cells

Sang-Im Lee, Soo-Kyung Kang, Ha-Jin Jung, Yang-Hyun Chun, Young-Dae Kwon, Eun-Cheol Kim

Clinical Oral Investigations.2015; 19(6): 1419.     CrossRef

Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages

Masashi Muroi, Ken-ichi Tanamoto

Toxicology Letters.2015; 235(3): 199.     CrossRef

Genetic variation in pattern recognition receptors: functional consequences and susceptibility to infectious disease

Martin Jaeger, Mark HT Stappers, Leo AB Joosten, Inge C Gyssens, Mihai G Netea

Future Microbiology.2015; 10(6): 989.     CrossRef

The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity

Özlem Yilmaz, Kyu Lim Lee

Periodontology 2000.2015; 69(1): 83.     CrossRef

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

KUANG PENG, LUSHAN LIU, DANGHENG WEI, YUNCHENG LV, GANG WANG, WENHAO XIONG, XIAOQING WANG, AFRASYAB ALTAF, LILI WANG, DAN HE, HONGYAN WANG, PENG QU

International Journal of Molecular Medicine.2015; 35(5): 1179.     CrossRef

Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia

Mariana Leticia Matias, Mariana Romão, Ingrid Cristina Weel, Vanessa Rocha Ribeiro, Priscila Rezeck Nunes, Vera Therezinha Borges, João Pessoa Araújo, José Carlos Peraçoli, Leandro de Oliveira, Maria Terezinha Peraçoli

PLOS ONE.2015; 10(6): e0129095.     CrossRef

Inflammation and Regeneration in the Dentin-Pulp Complex: A Double-edged Sword

Paul R. Cooper, Michelle J. Holder, Anthony J. Smith

Journal of Endodontics.2014; 40(4): S46.     CrossRef

NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn’s disease (CD), in Chinese Han population

Hong-xin Zhang, Zheng-ting Wang, Xiong-xiong Lu, Yan-gui Wang, Jie Zhong, Jie Liu

Inflammation Research.2014; 63(12): 979.     CrossRef

Natural Compounds and Aging: Between Autophagy and Inflammasome

Shih-Yi Chuang, Chih-Hung Lin, Jia-You Fang

BioMed Research International.2014; 2014: 1.     CrossRef

Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1βProduction Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages

Jing Bi, Shuang Song, Liurong Fang, Dang Wang, Huiyuan Jing, Li Gao, Yidong Cai, Rui Luo, Huanchun Chen, Shaobo Xiao

Mediators of Inflammation.2014; 2014: 1.     CrossRef

Resveratrol Mitigates Rat Retinal Ischemic Injury: The Roles of Matrix Metalloproteinase-9, Inducible Nitric Oxide, and Heme Oxygenase-1

Xiao-Qian Liu, Bing-Jhih Wu, Wynn H.T. Pan, Xiu-Mei Zhang, Jorn-Hon Liu, Mi-Mi Chen, Fang-Ping Chao, Hsiao-Ming Chao

Journal of Ocular Pharmacology and Therapeutics.2013; 29(1): 33.     CrossRef

NLRP3 Inflammasome and Host Protection against Bacterial Infection

Jwa-Jin Kim, Eun-Kyeong Jo

Journal of Korean Medical Science.2013; 28(10): 1415.     CrossRef

Molecular mediators of pulp inflammation and regeneration

Paul R. Cooper, Anthony J. Smith

Endodontic Topics.2013; 28(1): 90.     CrossRef

TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation

Shih-Yi Chuang, Chih-Hsiang Yang, Chih-Chang Chou, Yu-Ping Chiang, Tsung-Hsien Chuang, Li-Chung Hsu

Proceedings of the National Academy of Sciences.2013; 110(40): 16079.     CrossRef

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

Mark Verway, Manuella Bouttier, Tian-Tian Wang, Marilyn Carrier, Mario Calderon, Beum-Soo An, Emmanuelle Devemy, Fiona McIntosh, Maziar Divangahi, Marcel A. Behr, John H. White, Christopher M. Sassetti

PLoS Pathogens.2013; 9(6): e1003407.     CrossRef

Polymorphisms in the NLRP3 gene and risk of primary gouty arthritis

DONG-MEI MENG, YU-JIAO ZHOU, LUAN WANG, WEI REN, LING-LING CUI, LIN HAN, ZHENG-HAI QU, CHANG-GUI LI, JIA-JUN ZHAO

Molecular Medicine Reports.2013; 7(6): 1761.     CrossRef

A New Turnaround on the Urologist's Stance over the Inflammatory Signals

Khae Hawn Kim

International Neurourology Journal.2012; 16(1): 1.     CrossRef