Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome
Lori Birder, Karl-Erik Andersson
Int Neurourol J. 2018;22(Suppl 1):S3-9.   Published online 2018 Jan 31     DOI: https://doi.org/10.5213/inj.1835062.531
Citations to this article as recorded by Crossref logo
The urothelial barrier in interstitial cystitis/bladder pain syndrome: its form and function, an overview of preclinical models
Charlotte van Ginkel, Robert E. Hurst, Dick Janssen
Current Opinion in Urology.2024; 34(2): 77.     CrossRef
Lower Urinary Tract Inflammation and Infection: Key Microbiological and Immunological Aspects
Kayle Dickson, Juan Zhou, Christian Lehmann
Journal of Clinical Medicine.2024; 13(2): 315.     CrossRef
Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome
Ashu Mohammad, Mallory A. Laboulaye, Chen Shenhar, Amy D. Dobberfuhl
Nature Reviews Urology.2024;[Epub]     CrossRef
Therapeutic Effects of AF219 on Interstitial Cystitis/Bladder Pain Syndrome Induced by Cyclophosphamide or Water Avoidance Stress in Rats
Ibrahim Erkut Avci, Kerem Teke, Semil Selcen Gocmez, Murat Kasap, Gurler Akpinar, Busra Yaprak Bayrak, Gulsen Celebi, Mehmet Sarihan, Tijen Utkan, Cuneyd Ozkurkcugil
International Urogynecology Journal.2024;[Epub]     CrossRef
Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice
Preston E. Girardot, Xian Zhang, Nan Zhang, Kevin J. Donaldson, Micah A. Chrenek, Jana T. Sellers, Andrew J. Feola, Jack Papania, John M. Nickerson, Nieraj Jain, Jeffrey H. Boatright
Investigative Opthalmology & Visual Science.2024; 65(2): 28.     CrossRef
Repeated variate stress increased voiding frequency and altered TrpV1 and TrpV4 transcript expression in lower urinary tract (LUT) pathways in female mice
Amanda B. Sidwell, Celia McClintock, Katharine I. Beča, Susan E. Campbell, Beatrice M. Girard, Margaret A. Vizzard
Frontiers in Urology.2023;[Epub]     CrossRef
Changes in nerve growth factor signaling in female mice with cyclophosphamide-induced cystitis
Harrison W. Hsiang, Beatrice M. Girard, Margaret A. Vizzard
Frontiers in Urology.2023;[Epub]     CrossRef
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders
Francis M. Hughes, Michael R. Odom, Anissa Cervantes, Austin J. Livingston, J. Todd Purves
International Journal of Molecular Sciences.2023; 24(3): 2821.     CrossRef
The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models
Ana Catarina Neto, Mariana Santos-Pereira, Pedro Abreu-Mendes, Delminda Neves, Henrique Almeida, Francisco Cruz, Ana Charrua
Biomedicines.2023; 11(3): 696.     CrossRef
Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary Bladder
Dominika Peskar, Tadeja Kuret, Katja Lakota, Andreja Erman
International Journal of Molecular Sciences.2023; 24(6): 5758.     CrossRef
Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype
Ashti M. Shah, Yoram Vodovotz, Naoki Yoshimura, Christopher J. Chermansky, Jocelyn Fitzgerald, Pradeep Tyagi
Neurourology and Urodynamics.2023; 42(8): 1839.     CrossRef
Defining Molecular Treatment Targets for Bladder Pain Syndrome/Interstitial Cystitis: Uncovering Adhesion Molecules
Guldal Inal-Gultekin, Zeliha Gormez, Naside Mangir
Frontiers in Pharmacology.2022;[Epub]     CrossRef
Activation of translocator protein alleviates mechanical allodynia and bladder dysfunction in cyclophosphamide‐induced cystitis through repression of BDNF‐mediated neuroinflammation
Yong Huang, Minzhi Su, Chi Zhang, Hailun Zhan, Fei Yang, Zhentao Gao, Xiangfu Zhou, Bolong Liu
European Journal of Pain.2022; 26(6): 1234.     CrossRef
Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage
Zhinoos Taidi, Kylie J. Mansfield, Hafiz Sana-Ur-Rehman, Kate H. Moore, Lu Liu
Frontiers in Physiology.2022;[Epub]     CrossRef
Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells
Jin Kono, Masakatsu Ueda, Atsushi Sengiku, Sylvia O. Suadicani, Je Tae Woo, Takashi Kobayashi, Osamu Ogawa, Hiromitsu Negoro
International Journal of Molecular Sciences.2022; 23(9): 5037.     CrossRef
Experimental in vivo model to evaluate the impact of Cernitin™ on pain response on induced chronic bladder inflammation
Céline Augé, Nishtman Dizeyi, Lena Ramnemark, Philippe Lluel, Magnus Grabe
Scandinavian Journal of Urology.2022; 56(4): 320.     CrossRef
NLRP3+ macrophages aggravate inflammatory cystitis in diabetes
Yubing Peng, Yan Gao
Frontiers in Immunology.2022;[Epub]     CrossRef
Effects of pharmacological neurotrophin receptor inhibition on bladder function in female mice with cyclophosphamide-induced cystitis
Harrison W. Hsiang, Beatrice M. Girard, Lexi Ratkovits, Susan E. Campbell, Margaret A. Vizzard
Frontiers in Urology.2022;[Epub]     CrossRef
Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome
Jin Li, Xianyanling Yi, Jianzhong Ai
International Journal of Molecular Sciences.2022; 23(23): 14594.     CrossRef
Lacking transient receptor potential melastatin 2 attenuates lipopolysaccharide‐induced bladder inflammation and its associated hypersensitivity in mice
Jun Kamei, Naoki Aizawa, Takayuki Nakagawa, Shuji Kaneko, Tetsuya Fujimura, Yukio Homma, Haruki Kume, Yasuhiko Igawa
International Journal of Urology.2021; 28(1): 107.     CrossRef
Animal models of chronic pain. In vivo experiments
V. V. Khinovker, E. V. Khinovker
Regional Anesthesia and Acute Pain Management.2021; 14(3): 121.     CrossRef
Adenosine A2A Receptor Agonist Polydeoxyribonucleotide Alleviates Interstitial Cystitis-Induced Voiding Dysfunction by Suppressing Inflammation and Apoptosis in Rats
Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Kyu Yeoun Won, Yong Gil Na, Khae Hawn Kim, Su Jin Kim
Journal of Inflammation Research.2021; Volume 14: 367.     CrossRef
Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome
Hung-Jen Shih, Chao-Yuan Chang, Chung-Howe Lai, Chun-Jen Huang
Biomedicine & Pharmacotherapy.2021; 138: 111522.     CrossRef
Comparison of Intravesical Hyaluronic Acid, Chondroitin Sulfate, and Combination of Hyaluronic Acid-Chondroitin Sulfate Therapies in Animal Model of Interstitial Cystitis
Yavuz Onur Danacioglu, Bulent Erol, Seyma Ozkanli, Asif Yildirim, Ramazan Gokhan Atis, Mesrur Selcuk Silay, Turhan Caskurlu
International Neurourology Journal.2021; 25(1): 42.     CrossRef
THE RESULTS OF A PATOMORPHOLOGICAL ANALYSIS OF THE BLADDER WALL AT THE INTERSTITIAL CYSTITIS OR PAINFUL BLADDER SYNDROME IN AN EXPERIMENT
Rashad F. Sholan
Morphological newsletter.2021; 28(4): 55.     CrossRef
Anesthetic Bladder Capacity is a Clinical Biomarker for Interstitial Cystitis/Bladder Pain Syndrome Subtypes
Andre Plair, Robert J. Evans, Carl D Langefeld, Catherine A Matthews, Gopal Badlani, Stephen J. Walker
Urology.2021; 158: 74.     CrossRef
A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome
Tadeja Kuret, Dominika Peskar, Andreja Erman, Peter Veranič
Biomedicines.2021; 9(8): 865.     CrossRef
Nrf2 Pathway Ameliorates Bladder Dysfunction in Cyclophosphamide-Induced Cystitis via Suppression of Oxidative Stress
Bin Ni, Zhengsen Chen, Le Shu, Yunpeng Shao, Yi Huang, Nebiyu Elias Tamrat, Zhongqing Wei, Baixin Shen, Daniela Ribeiro
Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials
Michael J. Iadarola, Dorothy Cimino Brown, Alexis Nahama, Matthew R. Sapio, Andrew J. Mannes
Frontiers in Pharmacology.2021;[Epub]     CrossRef
P2X7 Receptor Blockade Protects Against Acrolein-Induced Bladder Damage: A Potential New Therapeutic Approach for the Treatment of Bladder Inflammatory Diseases
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Frontiers in Pharmacology.2021;[Epub]     CrossRef
Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain
Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Anja Hoffmann, Thomas M. Zollner, Philippa T.K. Saunders, Ioannis Simitsidellis, Ana Charrua, Francisco Cruz, Raul Gomez, Miguel Angel Tejada, Stephen B. McMahon, Laure Lo Re, Florent Barthas, K
Pain.2021; 162(9): 2349.     CrossRef
Urothelial Calcium-Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats
Wei-Yi Wu, Shih-Pin Lee, Bing-Juin Chiang, Wei-Yu Lin, Chiang-Ting Chien
Pharmaceuticals.2021; 14(10): 960.     CrossRef
The Role of PIEZO1 in Urinary Bladder Function and Dysfunction in a Rodent Model of Cyclophosphamide-Induced Cystitis
Katharine I. K. Beča, Beatrice M. Girard, Thomas J. Heppner, Grant W. Hennig, Gerald M. Herrera, Mark T. Nelson, Margaret A. Vizzard
Frontiers in Pain Research.2021;[Epub]     CrossRef
Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing
Hiroshi Hoshijima, Matthew Hunt, Hiroshi Nagasaka, Tony Yaksh
Journal of Pain Research.2021; Volume 14: 3521.     CrossRef
Review of Animal Models to Study Urinary Bladder Function
Jing-Dung Shen, Szu-Ju Chen, Huey-Yi Chen, Kun-Yuan Chiu, Yung-Hsiang Chen, Wen-Chi Chen
Biology.2021; 10(12): 1316.     CrossRef
A Novel Intravesical Dextrose Injection Improves Lower Urinary Tract Symptoms on Interstitial Cystitis/Bladder Pain Syndrome
Chin-Li Chen, Chien-Chang Kao, Ming-Hsin Yang, Gang-Yi Fan, Juin-Hong Cherng, Chih-Wei Tsao, Sheng-Tang Wu, Tai-Lung Cha, En Meng
Frontiers in Pharmacology.2021;[Epub]     CrossRef
Current and Future Directions of Stem Cell Therapy for Bladder Dysfunction
Jung Hyun Shin, Chae-Min Ryu, Hwan Yeul Yu, Dong-Myung Shin, Myung-Soo Choo
Stem Cell Reviews and Reports.2020; 16(1): 82.     CrossRef
Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats
Nathan A. Hirshman, Francis M. Hughes, Huixia Jin, William T. Harrison, Simon W. White, Isabelle Doan, Shelby N. Harper, Patrick D. Leidig, J. Todd Purves
American Journal of Physiology-Renal Physiology.2020; 318(2): F354.     CrossRef
Urinary bladder sigma-1 receptors: A new target for cystitis treatment
Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Miguel A. Tejada, Francisco R. Nieto, Manuel Merlos, Francisco J. Cañizares, Cruz M. Cendán, Eduardo Fernández-Segura, José M. Baeyens
Pharmacological Research.2020; 155: 104724.     CrossRef
Infiltration of Lymphocytes and Mast Cells to Bladder Tissues in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome
Sholan Rashad Farkhad Ogly
Nephro-Urology Monthly.2020;[Epub]     CrossRef
Astragalus polysaccharides and astragaloside IV ameliorates cyclophosphamide-induced mouse model of overactive bladder
Yung-Hsiang Chen, Wen-Chi Chen, Po-Len Liu, Huey-Yi Chen
Taiwanese Journal of Obstetrics and Gynecology.2020; 59(2): 248.     CrossRef
Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives
Yoshiyuki Akiyama, Yi Luo, Philip M Hanno, Daichi Maeda, Yukio Homma
International Journal of Urology.2020; 27(6): 491.     CrossRef
Characterization and Validation of a Chronic Model of Cyclophosphamide-Induced Interstitial Cystitis/Bladder Pain Syndrome in Rats
Céline Augé, Xavier Gamé, Nathalie Vergnolle, Philippe Lluel, Sophie Chabot
Frontiers in Pharmacology.2020;[Epub]     CrossRef
Diagnosis in a Preclinical Model of Bladder Pain Syndrome Using a Au/ZnO Nanorod-based SERS Substrate
Sanghwa Lee, Jung-Man Namgoong, Hwan Yu, Miyeon Jue, Gwanho Kim, Sangmin Jeon, Dong-Myung Shin, Myung-Soo Choo, Jinmyoung Joo, Chan-Gi Pack, Jun Kim
Nanomaterials.2019; 9(2): 224.     CrossRef
Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome
M. Martin Jensen, Wanjian Jia, Austin J. Schults, Kyle J. Isaacson, Douglas Steinhauff, Bryant Green, B. Zachary, Joseph Cappello, Hamidreza Ghandehari, Siam Oottamasathien
Biomaterials.2019; 217: 119293.     CrossRef
Experimental Cannabinoid 2 Receptor Activation by Phyto-Derived and Synthetic Cannabinoid Ligands in LPS-Induced Interstitial Cystitis in Mice
Geraint Berger, Nipun Arora, Ian Burkovskiy, Yanfang Xia, Anu Chinnadurai, Robert Westhofen, Georg Hagn, Ashley Cox, Melanie Kelly, Juan Zhou, Christian Lehmann
Molecules.2019; 24(23): 4239.     CrossRef
Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model
Amandeep Mahal, Nichole Young-Lin, Amy Dobberfuhl, Jaclyn Estes, Craig Vance Comiter
Investigative and Clinical Urology.2018; 59(4): 257.     CrossRef
A central role for Toll-like 4 receptors in interstitial cystitis?
Donna J. Sellers, Catherine McDermott, Russ Chess-Williams
American Journal of Physiology-Renal Physiology.2018; 315(4): F910.     CrossRef