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Int Neurourol J > Volume 17(1); 2013 > Article
Lee, Cho, Lee, Kim, and Oh: Short-term Effects of a Systematized Bladder Training Program for Idiopathic Overactive Bladder: A Prospective Study

ABSTRACT

Purpose:

This study was to investigate whether a systematized bladder training (BT) program is effective for patients with idiopathic overactive bladder (OAB).

Methods:

A prospective study was conducted on 105 patients with OAB from March 2009 to November 2011. We developed a 30 minutes BT program, which consisted of first, refraining from going to the bathroom after feeling an urge to void, second, in order to stop thinking about voiding, ceasing action and thought temporarily, and third, performing pelvic floor exercises 5 to 6 times. Before and after BT, the patients filled out voiding diaries as well as the following questionnaires; International Consultation on Incontinence Questionnaire for overactive bladder (ICIQ-OAB), International Prostate Symptom Score (IPSS), overactive bladder questionnaire (OAB-q), the short form 36-item health survey (SF-36) questionnaire, the work productivity and activity impairment questionnaire, and a patients’ perception of treatment benefit (PPTB).

Results:

A final analysis was performed from on 85 patients (38 male, 47 female) with idiopathic OAB. After the first BT, the results of the ICIQ-OAB showed improvement in frequency, nocturia, and urgency (P<0.05), and all domains of IPSS questionnaires showed significant improvement (P<0.05). Among the SF-36 domains, the role-physical domain showed significant improvement after the first BT, and the general health domain showed significant improvement after the second. The voiding diaries showed statistically significant changes in maximal voided volume after the first BT, and nocturia index and nocturnal polyuria index after the second BT. According to the PPTB questionnaire, the perceived usefulness of BT increased after each session, and almost all of the patients replied that BT improved their symptoms.

Conclusions:

Our results demonstrated that BT was effective in improving many OAB related symptoms and quality of life in patients with idiopathic OAB. More clinical application of BT could be implemented in the future.

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    INTRODUCTION

    Overactive bladder (OAB) is defined by the International Continence Society as symptoms of urgency, with or without urge incontinence, usually accompanied with frequency and nocturia [1]. Urgency is a sudden and compelling desire to pass urine that cannot easily be deferred, and is different from the normal strong desire to void in healthy persons. Idiopathic OAB (iOAB) is defined as OAB without underlying urological or neurologic diseases [2]. OAB has a major impact on depression, social isolation and a decline in general health (GH) and quality of life. The International Consultation on Incontinence (ICI) guidelines recommend pharmacotherapy and conservative treatment as a first-line therapy in OAB patients. Such conservative treatments include diet modification, pelvic floor muscle exercise, biofeedback, timed voiding and other bladder control programs that provide instructions to urgency or urge incontinence. Antimuscarinics can be added if these measures fail to control symptoms [3,4].
    Such behavioral intervention is suitable for primary care setting. Bladder training (BT) has been proven to improve urge urinary incontinence, and resolution rates have been reported to range from 12% to 73%, and improvement rates from 57% to 87% [5]. However, such protocols for BT vary from study to study [6]. Very few studies report on its efficacy, and there are even less prospective studies, Therefore, we aimed to investigate the efficacy of BT in patients with iOAB, using a systematized protocol.

    MATERIALS AND METHODS

    We prospectively enrolled 105 patients who presented with OAB from March 2009 to November 2011 in a BT program at our institution. Inclusion criteria were male and female patients more than 20 years old with iOAB. Patients who already took stable medications for OAB were included in the study, if they meet the inclusion criteria. We did not change the prescribed drugs; instead we only administered BT. Patients who were literate, agreed to informed consent, and willingly participated were included in the study. We excluded patients with a previous history of genito-urinary surgery, radical pelvic surgery, neurologic conditions such as cerebrovascular accidents, Parkinson’s disease, and spinal cord injuries. Medical history was taken, and clinical data was collected at the time of the first visit using a frequency-volume chart for 3 days, uroflowmetry with a measurement of postvoid residual urine volume, complete blood cell count test, test for electrolyte chemistry, urinalysis with microscopy, and urine culture to confirm underlying conditions.
    We developed a 30 minutes education program, modified from our experience in a previous education program developed at our institution used to treat nocturia [7]. The BT program we developed consisted of (1) education of normal daytime voiding frequency and amount, (2) watching videos about normal physiology of storing and emptying function of urine, (3) education of holding urine until a certain goal, and then aiming to increase the amount by 50 mL within 2 weeks, (4) then BT by first, refraining from going to the bathroom after feeling an urge to void, second, temporary cessation of action and thought, in order to stop thinking about voiding, and third, performing pelvic floor exercises 5 to 6 times, and (5) feedback and problem shooting with a specialized nurse practitioner (sl). Patients received reinforcement BT of the same educational content 1 month after the first BT.
    We obtained baseline questionnaires such as the International Prostate Symptom Score (IPSS), and International Consultation on Incontinence Questionnaire-Overactive bladder (ICIQ-OAB). The ICIQ questionnaires were previously linguistically validated by bilingual translators and approved for use by the International Consultation on Incontinence Modular Questionnaire Advisory Board (http://www.iciq.net/index.html). Patients completed overactive bladder questionnaires (OAB-q) which were also previously validated into Korean [8,9], as well as the Korean version of the short form 36-item health survey (SF-36) [10]. The Korean version of the SF-36 has been validated in previous studies and our study uses it with authorization [11,12]. The SF-36 questionnaire consists of 8 domains and 36 questions that aim to evaluate both physical and mental health-related quality of life (HRQoL). It consists of eight domains which are physical functioning (PF, 10 items), GH (5 items), mental health (MH, 5 items), bodily pain (BP, 2 items), role-physical (RP, 4 items), role-emotional (RE, 3 items), social functioning (SF, 2 items) and vitality (VT, 4 items). The higher the score sum, the higher the HRQoL [11]. A work productivity and activity impairment questionnaire (WPAI-GH) was also obtained before and after BT [13]. Patients’ perception of treatment benefit (PPTB) was graded as no benefit, little benefit, or much benefit to measure the level of self-perceived improvement with BT [14]. Before BT, and after each session, patients were asked to complete the above-mentioned questionnaires. In addition, we developed a questionnaire which evaluated the perspective of BT and analyzed the responses we obtained after each BT session. They also filled out voiding diaries before and after each BT session.
    Patients who did not return after each BT session were contacted by telephone of the nurse practitioner and asked questions to evaluate the self-perceived improvement rate of BT at the end of the study period. The primary outcome was urinary parameters measured by ICIQ-OAB, IPSS, OAB-q, and the secondary outcome was daytime and nocturnal number of voids.
    A descriptive analysis was performed with the independent t-test method. A 2-sided chi-square test analysis was performed using the IBM SPSS ver. 18.0 (IBM Co., Armonk, NY, USA). A P-value lower than 0.05 was considered to be statistically significant. This study was approved by the Institutional Review Board of Seoul National University Hospital (0812-010-264).

    RESULTS

    Eighty-five patients with iOAB were found to be eligible for analysis. The demographics of these patients were as following. The average age of the patients was 56.7±15.9 years. Thirty-eight patients (44.7%) were male, and 47 (55.3%) were female. The average follow up period was 13.5 ±12.8 weeks. Their socioeconomic status and voiding-related behavioral factors were also shown in Table 1.
    The changes of questionnaires before and after each BT session were recorded and analyzed. After the first BT session the ICIQ-OAB showed improvement in frequency, nocturia, and urgency (P<0.05), although incontinence did not show significant improvement. All domains of IPSS questionnaires also showed significant improvement (P<0.05). Among the SF-36 domains, the RP domain showed significant improvement after the first BT, and the GH domain showed significant improvement after the second BT (Table 2). After the second BT session, compared to the improvement after the first BT session, the improvement was not statistically significant, however, the improvement of the GH domain of the SF-36 questionnaire was significant. The results of the WPAI-GH obtained before and after BT are listed in Table 3. The patients reported that after BT, they missed less work hours, and worked more hours, although these changes were not statistically significant.
    The results of the PPTB after BT were analyzed (Table 4). Sixty-three patients (91.3%) replied that their symptoms improved after the first BT, and 37 patients (94.8%) replied that the second session of BT improved their symptoms after completion of BT. According to a self-developed questionnaire evaluation the patient’s perspective of BT, after each BT session, patients answered that strong contraction of pelvic muscles was most useful in holding urine, and that incontinence when holding urine was the most difficult factor during BT.
    The voiding diaries showed statistically significant changes after the first BT in maximal voided volume, and after the second BT, nocturia index and nocturnal polyuria index showed significant improvement after the second BT session compared with the first BT (Table 5).

    DISCUSSION

    OAB is a common distressing condition and its prevalence increases with age [15]. Such a condition not only lowers the productivity and quality of life of the patients, but also increases socioeconomic costs, which is why it deserves attention [16].
    In order to treat OAB, pharmacotherapy with antimuscarinic agents has been used as a first line treatment for OAB. However, such medication has a strong placebo effect with marginal efficacy, and due to side effects such as dry mouth, compliance and persistence rates are low. Behavioral treatments do not have such shortcomings, and have been used for several decades [4]. They have been adopted by several disciplines and are implemented in many different ways. The spectrum of behavioral treatments includes those that target voiding habits and life style, as well as those that train pelvic floor muscles to improve strength and control. What they all have in common is that they improve symptoms by teaching skills and by changing the patient’s behavior. Among such treatments, BT is a behavioral intervention developed originally for the treatment of urge incontinence. The goal of BT is to break the cycle in which habitual frequent urination can reduce bladder capacity and lead to bladder over-activity, which in turn causes urge incontinence. BT introduces consistent incremental voiding schedules to reduce voiding frequency, increase bladder capacity, and restore normal bladder function [17]. BT offers an approach to OAB that avoids the side effects of anticholinergic medications, which is promising in that it aims to improve bladder control through systematic changes in patient behavior and learning bladder control skills [18]. Therefore, we can also positively consider systematizing out BT protocol and broadening the range of application.
    A few studies support the efficacy of BT, however, the short-term follow-up of most studies is pointed out as a limitation, because OAB usually requires long-term treatment [19]. In addition, although previous studies report that BT shows equivalent or superior efficacy compared to pharmacotherapy, many clinics do not have sufficient time, funding or appropriately qualified staff to provide a BT service, making it difficult to apply in clinical practice.
    In our study, we analyzed the effect of a systematized BT in patients with iOAB. We measured the subjective symptom change of patients before and after BT with objective tools such as questionnaires. The questionnaire information of a few patients who did not visit our outpatient clinic after receiving both sessions of BT was obtained by a follow-up telephone interview. We considered this as reliable, because the patients’ recollection of their most recent status was accurate. The significant improvement of ICIQ-OAB scores after the first BT session shows that BT can be effective in improving the subjective symptoms of the patients.
    The results of the ICIQ-OAB questionnaire are interesting, in that frequency, nocturia, and urgency all improved, yet the improvement of incontinence was not significant. In previous studies, incontinence was proved to be significantly improved by BT in women. Our study did not show such significant improvement, probably because incontinence is a strong symptom, not easy to defer by BT alone. Our patients mostly suffered from OAB-dry [20]. Our study showed significant improvement in symptoms that were previously considered to be predominant in male patients [18]. Although our study included more female patients than male patients, such results suggest the broader range of applicability of BT in the future.
    The SF-36 showed significant improvement in only physical symptoms and vitality, but this can be attributed to the fact that this questionnaire is a generic questionnaire, with lower specificity compared to the other questionnaires [21]. The reduction of loss of working hours, and increase of actual working hours after BT measured by the WPAI-GH show that BT can be beneficial in increasing productivity, and thus increase patient satisfaction of work efficacy. The replies of the patients to the PPTB after systematized BT also provide valuable information. Our results suggested that a BT can be effective in improving symptoms and QoL of patients with OAB, and patients highly considered the program to be useful after completion of both sessions. The fact that patients actually considered strong contraction of pelvic muscles to be useful in holding urine indirectly suggests the usefulness of BT (Table 4).
    Why the statistical significance of the effect of BT was lower after the second session than the first session is worth consideration. We attributed this difference to the fact that patients already knew the contents of BT after the first session, and therefore, the effect of the second BT might have been weaker. In addition, most of the patients who perceived the BT to be effective after the first session did not visit our institution for a second follow-up. The low number of patients at final follow-up could also be an indicator of the effectiveness of BT.
    According to the voiding diaries, although the number of daytime voids showed no change after BT, the maximal voided volume increased significantly after first BT. In the other questionnaires we analyzed, the urgency the patients felt per each void significantly improved. The reason the number of voids did not improve on voiding diary analysis was probably due to a selection bias due to the small number of patients who filled up voiding diaries on follow-up. Therefore, detailed analysis of number of daytime voids is necessary in the future
    This study has a few limitations. First of all, we lost quite a few patients at final follow-up, thus this limited number of patients may have created selection bias in our investigation. Also, quite a few patients failed to record their voiding diaries, causing a loss in information of number of voids, and nocturia variables. In addition, this study is a single arm study. In the future, a prospective randomized controlled study is warranted to explore the efficacy of BT or pharmacotherapy in iOAB. Also, we excluded neurologic OAB patients, which would also benefit from additional analysis in the future.
    Our study demonstrated that BT in patients diagnosed with iOAB is effective in improving QoL, work productivity, and voiding symptoms, and is perceived to be useful in improving symptoms. In order to obtain more information, more detailed studies are necessary in the future.

    ACKNOWLEDGEMENTS

    We are obliged to Mrs. Yu Kyung Lee for valuable help in database management.

    NOTES

    CONFLICT OF INTEREST
    No potential conflict of interest relevant to this article was reported.

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    Table 1
    Patient demographics
    Parameter Analyzed group (n=85)
    Age (yr) 56.7±15.9
    Gender
      Male 38 (44.7)
      Female 47 (55.3)
    Follow-up period (mo) 13.5±12.8
    Other surgery
      Benign uterine surgery 7 (8.2)
      Benign anorectal surgery 2 (2.4)
      Benign spine surgery 1 (1.2)
      Others 16 (18.8)
      None 58 (68.2)
    Other diseases
      Brain or spine disease 3 (1.2)
      Diabetes mellitus 8 (9.4)
      None 75 (88.3)
    Marital status
      Married and living with partner 63 (74.1)
      Partner deceased 3 (3.5)
      Divorced 4 (4.7)
      Living separately 1 (1.2)
      Unmarried 12 (14.1)
    Occupation
      Agriculture 3 (3.5)
      Manufacture 4 (4.7)
      Office worker 6 (7.1)
      Housewife 8 (9.4)
      Unemployed 36 (42.4)
      Retired 10 (11.8)
      Student 5 (5.9)
    Final education
      Uneducated 1 (1.2)
      Elementary school 6 (7.1)
      Middle school 11 (12.9)
      High school 23 (27.9)
      College 44 (51.8)
    Average monthly income (KRW)
      Less than 1,000,000 16 (18.8)
      1,000,000–1,990,000 14 (16.5)
      2,000,000–2,990,000 16 (18.8)
      3,000,000–3,990,000 16 (18.8)
      4,000,000–4,990,000 7 (8.2)
      More than 5,000,000 14 (16.5)

    Values are presented as mean±standard deviation or number (%). KRW, Korean Won (the currency of South Korea).

    Table 2
    Change of questionnaire scores before and after bladder training
    (A) Baseline (n=85) (B) 1st Education (n=69) (C) 2nd Education (n=39) P-valuea)
    Between (A) and (B) Between (B) and (C)
    ICIQ-OAB
      Total 6.2±2.2 4.2±2.6 3.4±1.6 <0.001 0.058
      Frequency 1.7±1.2 0.8±1.2 0.5±0.6 <0.001 0.054
      Nocturia 1.9±1.1 1.3±1.0 0.5±0.6 <0.001 0.800
      Urgency 2.0±1.1 1.5±1.2 1.2±1.0 0.004 0.243
      Incontinence 0.6±0.8 0.5±0.6 0.5±0.6 0.278 0.058
    IPSS
      IPSS-SS 8.2±3.0 5.6±2.7 5.5±3.0 <0.001 0.328
      IPSS-VS 9.0±6.0 7.2±5.1 6.3±4.5 <0.001 0.809
      IPSS-TS 17.2±8.0 12.8±6.8 11.8±6.6 <0.001 0.155
      IPSS-Q8 86.8±32.1 69.5±28.9 67.1±28.1 <0.001 0.385
    OAB-q
      Symptom severity 23.4±7.5 18.3±7.6 17.3±6.5 <0.001 0.273
      Coping 21.5±11.0 17.6±9.4 16.6±9.7 <0.001 0.541
      Concern 18.2±8.3 14.4±8.30 14.0±6.6 <0.001 0.833
      Sleep 14.1±6.7 11.0±5.0 10.8±4.7 <0.001 0.680
      Social interaction 9.4±5.0 8.0±3.9 8.0±4.1 0.001 0.599
      HRQoL total 63.0±26.3 51.1±22.6 49.6±22.6 <0.001 0.564
    SF-36
      Physical function 24.5±5.0 24.7±3.8 25.3±3.9 0.085 0.166
      Role-physical 15.2±4.6 16.1±4.5 16.0±4.0 0.017 0.235
      Bodily pain 4.4±2.3 4.7±2.5 4.7±2.3 0.388 0.632
      General health 15.9±2.2 16.2±1.9 15.7±2.3 0.193 0.047
      Vitality 14.4±2.9 14.2±2.4 14.1±2.3 0.212 0.715
      Social functioning 6.0±0.8 5.8±0.7 6.1±0.98 0.141 0.173
      Role-emotional 11.8±3.3 12.3±3.2 12.2±3.0 0.110 0.711
      Mental health 16.9±2.7 17.2±2.4 17.0±2.5 0.342 0.772

    Values are presented as mean±standard deviation.

    ICIQ-OAB, International Consultation on Incontinence Questionnaire for overactive bladder; IPSS, International Prostate Symptom Score; SS, storage symptoms; VS, voiding symptoms; TS, total score; OAB-q, overactive bladder questionnaires; HRQoL, health-related quality of life; SF-36, short form 36-item health survey.

    a) Analyzed by paired t-test.

    P<0.05.

    Table 3
    Work productivity and activity impairment questionnaire
    (A) Baseline (n=85) (B) 1st Education (n=69) (C) 2nd Education (n=39) P-valuea)
    Between (A) and (B) Between (B) and (C)
    General
      Employed 17 (20.0) 17 (24.6) 8 (20.5) 0.046.6a), 1.000a)
      Work hoursc) 44.6±19.1 45.4±26.0 61.7±18.2 0.253b) 0.815b)
    Work productivity and activity impairment dimensions
      Work hours missed due to health 0.6±1.7 10.8±27.7 3.1±4.1 0.2774b) 0.0764b)
      Work impairment due to health 17.6±14.4 24.1±29.2 21.3±23.6 0.820b) 0.465b)
      Overall work impairment due to health 17.3±14.6 26.2±33.3 23.0±25.0 0.986b) 0.257b)
      Activity impairment due to health 34.2±28.3 32.7±26.6 31.3±27.6 0.477b) 0.944b)

    Values are presented as number (%) or mean±standard deviation.

    a) Analyzed by Wilcoxon signed rank test.

    b) Analyzed by paired t-test.

    c) All work hours were per week.

    P<0.05.

    Table 4
    Patients’ perception of treatment benefit (PPTB) after bladder training and patients’ perspective of bladder training
    After 1st education (n=69) After 2nd education (n=39)
    PPTB
      How effective was this treatment for you?
        Not effective 6 (8.7) 2 (5.1)
        Slightly effective 36 (52.2) 19 (48.7)
        Very effective 27 (39.1) 18 (46.2)
      How much did your symptoms improve after education?
        75–100% 11 (15.9) 8 (20.5)
        50–75% 16 (23.2) 12 (30.8)
        25–50% 21 (30.4) 10 (25.6)
        Less than 25% 13 (18.8) 8 (20.5)
        No improvement 7 (10.1) 1 (2.6)
        Worsened 0 (0) 0 (0)
        No answer 1 (1.4) 0 (0)
    Patients’ perspective of bladder training
      Which mode was most useful for holding urine?
        Nothing in particular 12 (17.4) 6 (15.4)
        Avoiding going to bathroom 19 (27.5) 10 (25.6)
        Deep breathing or thinking of something else 16 (23.2) 8 (20.5)
        Strong contraction of pelvic muscles 20 (29.0) 15 (38.5)
        No answer 2 (2.9) 0 (0)
      Which was most difficult when holding urine?
        Abdominal pain or other physical discomfort 8 (11.6) 9 (23.1)
        I could not concentrate on anything other activities 16 (23.2) 7 (17.9)
        Incontinence when holding urine 19 (27.5) 10 (25.6)
        After holding urine, experience of difficulty voiding 7 (10.1) 9 (23.1)
        No answer 19 (27.5) 4 (10.3)

    Values are presented as number (%).

    Table 5
    Voiding diary
    Variable (A) Baseline (n=38) (B) 1st Education (n=38) (C) 2nd Education (n=35) P-valuea)
    Between (A) and (B) Between (B) and (C)
    Day time frequency 6.6±2.5 6.8±3.1 7.3±3.8 0.502 0.730
    Nocturia 1.2±1.1 1.2±1.4 0.7±0.9 1.000 0.056
    Total voiding count 7.8±2.6 8.1±3.5 7.9±3.8 0.547 0.743
    Mean voided volume 239.2±84.4 234.6±83.0 215.4±86.0 0.604 0.394
    Maximal voided volume 355.3±111.5 386.3±127.3 326.3±130.9 0.047 0.076
    Nocturia index 1.0±0.8 0.8±0.7 0.5±0.7 0.078 0.045
    Nocturnal polyuria index 0.19±0.15 0.17±0.15 0.11±0.13 0.167 0.024

    Values are presented as mean±standard deviation.

    a) Analyzed by paired t-test.

    P<0.05.

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    Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
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    Department of Urology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine,
    29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea
    Tel: +82-2-2001-2237     Fax: +82-2-2001-2247    E-mail: choys1011@naver.com

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