Commentary on “Risk Factors for Transurethral Coagulation for Hemostasis During Holmium Laser Enucleation of the Prostate”

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Int Neurourol J. 2022;26(4):353-354
Publication date (electronic) : 2022 December 30
doi :
Fortis hospital Mulund, Mumbai, India
Corresponding author: Pankaj N. Maheshwari Fortis Hospital Mulund, Mulund West, Mumbai 400080, India Email:
Received 2022 October 9; Accepted 2022 November 23.

To the editor,

We read the manuscript, ‘Risk factors for transurethral coagulation for hemostasis during holmium laser enucleation of the prostate,’ by Yoon et al. [1] with huge interest. We would like to complement the authors for a large experience in holmium laser enucleation of the prostate (HoLEP) and an interesting account of need of electro-cautery during the procedure.

The need for electro-cautery coagulation in 22.8% patients is indeed very high. It was used in about 19.1% to make the vision clearer for morcellation but even 3.7% for bleeding that could not be controlled by laser coagulation is high.

HoLEP as a part of management protocol has been available for more than 2 decades and apart from the initial learning curve, electro-coagulation is rarely needed. It is very difficult to agree with the conclusion that the risk of electro-coagulation increases in patients with transitional zone volume >35 mL. HoLEP is indicated for large volume adenoma [2] and the proposed odds ratio for need for coagulation of 5.17 in ≥53.5-mL adenoma appears very high. The very fact that most recent guidelines propose HoLEP as a treatment of choice for large prostate volumes and for patients on antiplatelet or anticoagulant medications is a testament for its coagulation capabilities [3].

The authors presumption that the risk of bleeding increases as the prostate volume increases because the larger the prostate, the more blood supply is required, and thus, the blood vessel density increases may not hold true for HoLEP as in contrast to transurethral resection of the prostate where we resect through the adenoma, during HoLEP the procedure is performed at the capsular level hence the blood vessel density in the prostatic tissue will not have an impact.

We would like to provide our tips for reducing bleeding and hence need for electro-coagulation.

  • (1) Use the laser at the highest possible frequency. The simultaneous coagulation is better at higher frequency.

  • (2) During the dissection, it is important to remain on the capsule. The bleeding is more if you cut through the tissue.

  • (3) Bleeding increases if there are capsular perforation. Being aware and avoiding them is important.

  • (4) Dissect by nontouch technique by the plasma of the laser and not by direct cutting.

  • (5) If bleeding is still there, a catheter with light traction and irrigation for a few minutes controls most bleeding.

  • (6) If the bleeding is still significant to make morcellation difficult than either electro-coagulation or staging the procedure would help.

One important reason for bleeding that needs electro-coagulation is the bleeding related to morcellation injury. The bladder mucosal injury is difficult to coagulate with laser. Although we agree that electro-surgical back-up is important during HoLEP, once you cross the learning curve, the need should be very rare.


Conflict of Interest

No potential conflict of interest relevant to this article was reported.


1. Yoon HS, Kim MH, Park JS, Choo MS, Jeong SJ, Oh SJ. Risk factors for transurethral coagulation for hemostasis during holmium laser enucleation of the prostate. Int Neurourol J 2022;26:153–60.
2. Yilmaz M, Karaaslan M, Aybal HC, Ferry von Bargen M, Tonyali S, Toprak T, et al. Laser enucleation of the prostate in men with very large glands ≥175 ml: a systematic review. Ann Med Surg (Lond) 2022;80:104279.
3. Abedi A, Razzaghi MR, Rahavian A, Hazrati E, Aliakbari F, Vahedisoraki V, et al. Is holmium laser enucleation of the prostate a good surgical alternative in benign prostatic hyperplasia management? A Review Article. J Lasers Med Sci 2020;11:197–203.

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