Editorial for ‘Lower Urinary Tract Symptoms: Clinical and Translational Science’

Article information

Int Neurourol J. 2024;28(Suppl 1):S1-1
Publication date (electronic) : 2024 February 29
doi : https://doi.org/10.5213/inj.2424edi01
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Corresponding author: Lori A. Birder Email: lbirder@pitt.edu

Welcome to this special issue of International Neurourology Journal which includes articles highlighting a broad range of research for the topic of ‘Lower Urinary Tract Symptoms: Clinical and Translational Science.’

This issue includes articles covering how detrusor overactivity (DO) in rats is associated with increased levels of the transmitter adenosine triphosphate, a mediator linked with induction of DO [1]; a study on the negative impact of aging on the distribution of bladder afferent nerves which can result in changes in the bladder sensory-web leading to increased lower urinary tract symptoms in older adults [2]; an examination of the pathophysiology of overactive bladder and pharmacologic treatments from a basic research perspective [3]; a review discussing the benefits of ketone bodies as an energy source to reduce the risks of metabolic syndrome (which impacts both cardiovascular and bladder functions) [4]; a study examining how synergistic responses of alpha-adrenergic and muscarinic receptor stimulation can lead to a supracontractile response in human hyperplastic prostate tissue which may be important in treating benign prostatic hyperplasia conditions [5]; and how application of the Sleep C.A.L.M. (Sleep disorders, Medical comorbidities, Actions, Lower urinary tract dysfunction, and Medications) system, which categorizes factors that may reflect most underlying causes of nocturia, is associated not only with increased odds of nocturia but also a means to organize the various etiologies for nocturia in community-dwelling adults [6]. We hope you enjoy the articles presented in this special issue.


Conflict of Interest

No potential conflict of interest relevant to this article was reported.


1. Vale L, Cruz F, Charrua A. Detrusor overactivity after partial bladder outlet obstruction is associated with high urinary adenosine triphosphate levels in female Wistar rats. Int Neurourol J 2024;28(Suppl 1):S34–9.
2. de Rijk MM, Peter S, Wolf-Johnston A, Heesakkers J, van Koeveringe GA, Birder LA. Quantification of aging-related decreases in sensory innervation of the bladder trigone in rats. Int Neurourol J 2024;28(Suppl 1):S40–5.
3. Kwon J, Kim DY, Cho KJ, Hashimoto M, Matsuoka K, Kamijo T, et al. Pathophysiology of overactive bladder and pharmacologic treatments including β3-adrenoceptor agonists -basic research perspectives-. Int Neurourol J 2024;28(Suppl 1):S12–33.
4. Faria-Costa G, Oliveira J, Vilas-Boas I, Campelo I, Silva EA, BrásSilva C, et al. The ketone bridge between the heart and the bladder: how fast should we go? Int Neurourol J 2024;28(Suppl 1):S2–11.
5. Blake-James BT, Chakrabarty B, Fry CH. Adreno-muscarinic synergy of contractile responses from human hyperplastic prostate. Int Neurourol J 2024;28(Suppl 1):S46–54.
6. Boroda JU, De Leon B, Khosla L, Chobufo MD, Rahman SN, Lazar JM, et al. Application of the Sleep C.A.L.M. tool for assessing nocturia in a large nationally representative cohort. Int Neurourol J 2024;28(Suppl 1):S155–61.

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