INJ Search


Int Neurourol J > Volume 18(1); 2014 > Article
Chae, Bae, Yoon, Park, Moon, Lee, and Oh: Female Urethral Condyloma Causing Bladder Outlet Obstruction


In women, urethral condyloma rarely leads to a bladder outlet obstruction. A 39-year-old woman who presented with frequency, urgency, and residual urine sensation was found to have a condyloma in her urethral meatus. Urodynamic study indicated bladder outlet obstruction. After condyloma excision, she returned to normal voiding, and the free maximum flow rate improved. In women, excision of urethral condylomas that cause obstruction can be an effective treatment with early recovery of voiding function.


    Condyloma acuminata is often reported to develop in adult anal or genital regions. However, it rarely occurs in the female urethra and seldom causes bladder outlet obstruction (BOO). We report a case of urethral condyloma in a woman who presented BOO-related voiding symptoms.


    A 39-year-old woman presented to our hospital complaining of frequency, urgency, and sensation of incomplete bladder emptying. Urinalysis revealed no microscopic hematuria or pyuria, and her urine culture remained sterile. An uroflowmetry was performed, and the free maximum flow rate (Qmax) was low at 14 mL/sec, with voided volume at 218 mL, and postvoid residual urine volume (PVR) at 25 mL. She was administered an alpha blocker for two weeks, but there was no symptom improvement. A follow-up uroflowmetry showed an even lower Qmax at 8 mL/sec, with voided volume at 206 mL, and PVR at 45 mL. To rule out any anatomical obstructing lesions, a physical examination was performed, and multiple small papillary masses were noted around the external urethral meatus (Fig. 1).
    The rapid plasma reagin card test and Treponema pallidum hemagglutination test results were negative. Cystourethroscopy demonstrated nonspecific findings in the urethra and bladder. An urodynamic study revealed a detrusor pressure at maximum flow rate (PdetQmax) at 25 cm H2O with Qmax at 14 mL/sec, indicating BOO. The masses were surgically excised, and primary repair was performed. Histopathological examination indicated condyloma acuminata with papillomatosis, acanthosis, parakeratosis, and hyperkeratosis (Fig. 2).
    Excision of the masses resulted in near complete resolution of her symptoms. No obvious recurrence of condyloma acuminata has been observed for 6 months after the surgery. One month after the surgical excision, a follow-up uroflowmetry showed an improved Qmax, voided volume, and PVR at 17 mL/sec, 229 mL, and 10 mL, respectively.


    There are no absolute criteria to define female BOO so far, but several reports have indicated that a Qmax less than 15 mL/sec combined with a PdetQmax greater than 20 cm H2O in a pressure-flow study is associated with obstructive symptoms [1]. In women, BOO can present with various types of symptoms. Typical complaints of slow urinary flow and difficult emptying are highly indicative of BOO. Many other voiding problems such as irritative voiding complaints following BOO make it more difficult to diagnose [2]. This reinforces the need for a thorough investigation in women with BOO, including careful history taking and physical examination, with other appropriate imaging, functional studies.
    The causes of BOO can be classified as anatomical or functional [3]. In women, anatomical causes of BOO include extrinsic compression by Skene's gland cysts, diverticulum, and Gartner's duct remnants. Moreover, genitourinary malignancy including urethral cancer and numerous gynecologic cancers can induce urinary obstruction and should always be considered in the diagnostic algorithm.
    Condyloma acuminata is a common sexually transmitted disease caused by the human papillomavirus infection [4]. It is mostly found in young adults between 17-33 years of age, and the incubation period varies from weeks to months [5]. Associated symptoms such as split stream, dysuria, urethral bleeding, and infection are not so common. Condyloma acuminata consists of soft, papillary growths occurring singly or in clusters, and presents in moist areas such as the genitalia, rectum, and urethra. Urethral condyloma is relatively uncommon in both men and women. Even more uncommon is the occurrence of BOO due to urethral condyloma. Various treatment methods have been used, including 5-fluorouracil, interferon, electrocoagulation, cryotherapy, photodynamic therapy, carbon dioxide laser, and local excision. Condyloma treated with electrocoagulation or laser evaporation has high recurrence rates, and urethral stenosis, erosion, and adhesion can occur as complications [6].
    In conclusion, female urethral condyloma is a rare entity, and it rarely causes BOO. It should be considered as a differential diagnosis in women presenting with obstructive voiding symptoms associated with a urethral mass. The present case emphasizes that a thorough physical examination should be performed in young women with signs of BOO. In women, excision of urethral condylomas causing obstruction can be an effective treatment with early recovery of voiding function.


    No potential conflict of interest relevant to this article was reported.


    1. Massolt ET, Groen J, Vierhout ME. Application of the Blaivas-Groutz bladder outlet obstruction nomogram in women with urinary incontinence. Neurourol Urodyn 2005;24:237-242. PMID: 15747342.
    crossref pmid
    2. Kaufman MR, Scarpero H, Dmochowski RR. Diagnosis and management of outlet obstruction in the female. Curr Opin Urol 2008;18:365-369. PMID: 18520756.
    crossref pmid
    3. Goldman HB, Zimmern PE. The treatment of female bladder outlet obstruction. BJU Int 2006;98(Suppl 1):17-23. PMID: 16911596.
    crossref pmid
    4. Scheurer ME, Tortolero-Luna G, Adler-Storthz K. Human papillomavirus infection: biology, epidemiology, and prevention. Int J Gynecol Cancer 2005;15:727-746. PMID: 16174218.
    crossref pmid
    5. Kilciler M, Bedir S, Erdemir F, Coban H, Erten K, Ors O, et al. Condylomata acuminata of external urethral meatus causing infravesical obstruction. Int Urol Nephrol 2007;39:107-109. PMID: 17268907.
    crossref pmid
    6. Fathi R, Tsoukas MM. Genital warts and other HPV infections: Established and novel therapies. Clin Dermatol 2014;32:299-306. PMID: 24559567.
    crossref pmid
    Fig. 1
    Urethral condyloma around the female urethra.
    Fig. 2
    A villous connective tissue stroma covered by a thickened hyperkeratotic epithelium with hematoxylin and eosin stain (×40).
    Share :
    Facebook Twitter Linked In Google+
    METRICS Graph View
    • 7 Web of Science
    • 11 Crossref
    • 11 Scopus
    • 11,182 View
    • 53 Download
    We recommend

    Article Category

    Browse all articles >


    Browse all articles >


    Browse all articles >


    Browse all articles >


    Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
    Editorial Office
    Department of Urology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine,
    29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea
    Tel: +82-2-2001-2237     Fax: +82-2-2001-2247    E-mail:

    Copyright © 2024 by Korean Continence Society.

    Developed in M2PI

    Close layer
    prev next