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Int Neurourol J > Volume 12(1); 2008 > Article
Clinical Investigation
Journal of the Korean Continence Society 2008;12(1): 19-26.
Efficacy and Safety of Doxazosin GITS over 4 weeks for the Treatment of Non-neurogenic Voiding Dysfunction in Females: Short-term Outcomes.
Kyu Sung Lee, Deok Hyun Han, Ji Young Kim, Jin Woo Chung, Seol Ho Choo, Joon Chul Kim, Ju Tae Seo, Myung Soo Choo
1Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Urology, College of Medicine, Catholic University of Korea, Kangnam St Mary's Hospital, Seoul, Korea.
3Department of Urology, Kwandong University College of Medicine, Cheil General hospital & Women's Healthcare Center, Seoul, Korea.
4Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
We administered doxazosin gastrointestinal therapeutic system (GITS) to women with non-neurogenic voiding dysfunction to evaluate its therapeutic effects.
Women who had voiding dysfunctions for at least 3 mo were included. Inclusion criteria were age > or =18yr, an International Prostate Symptom Score (IPSS) > or =15, and a maximum flow rate (Qmax) <15mL/sec and/or postvoid residual (PVR) > or =150mL. Patients with neurogenic voiding dysfunction or anatomical bladder outlet obstruction were excluded. All patients were classified according to the Blaivas-Groutz nomogram. After 4 weeks, treatment outcomes were evaluated.
Sixty-two patients were evaluated of mean age 53.8 (32-78)yr. According to the Blaivas-Groutz nomogram, 24 patients had no or mild obstruction (group A) and 38 had moderate or severe obstruction (group B). After treatment, mean IPSS decreased significantly and by more than 5 points in 42 (67.7%). Mean bother scores, Qmax, and PVR also changed significantly. Thirty-seven (59.7%) showed Qmax increases of more than 50%. No significant difference were observed between the groups in terms of IPSS, bother score, Qmax, PVR, micturition frequencies, or functional bladder capacity changes. Adverse effects related to medication were de novo stress urinary incontinence (SUI) (1 case) and underlying SUI aggravation (1 case). By satisfaction assessments, 16 patients (25.8%) were 'mainly satisfied', 31 (50%) were 'slightly satisfied', and 15 (24.2%) were 'dissatisfied'.
Doxazosin GITS was found to be effective in female patients with voiding dysfunction regardless of obstruction grade. The alpha-adrenoceptor antagonists should be viewed as initial treatment option for women with a non-neurogenic voiding dysfunction.
Keywords: Urinary bladder neck obstruction; Female; Alpha-adrenergic receptor blockers; Outcome assessment
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Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
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