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Int Neurourol J > Volume 9(2); 2005 > Article
Clinical Investigation
Journal of the Korean Continence Society 2005;9(2): 75-81.
DOI: https://doi.org/10.5213/jkcs.2005.9.2.75   
Effects of the Single Administration of the Anticholonergics, Trospium Chloride, on the Patients with Nocturia.
Jin Wen, Dong Il Kang, Sung Hyup Choi, Kweon Sik Min
1YanBian Maternal and Child Hygiene Hospital, China.
2Department of Urology, Pusan Paik Hospital, Inje University, Busan, Korea.
3Paik Institute of Clinical Research, Inje University, Busan, Korea. kweonsikmin@medimail.co.kr
ABSTRACT
PURPOSE
The aim of this study was to evaluate the effects of the single administration of the anticholonergics, trospium chloride, in the nocturic patients without bladder outlet obstruction for mid-term.
MATERIALS AND METHODS
We included the 22 male and 102 female patients with nocturia over 3 times and without bladder outlet obstruction. Exclusion criteria was under 15 ml/sec in maximal flow rate, over 30 ml in post-void residual urine, nocturnal polyuria and medication affecting lower urinary tract symptoms including alpha-blockers, sedatives, muscle relaxants. Based on voiding diary for 3 days, frequency of the nocturia, daytime frequency and frequency of the urgency and urge incontinence were measured at pretreatment, post-treatment 1st month, 3rd month and 6th month. Additionally maximal flow rate and post-void residual urine were also recorded at the same periods. Anticholinergics was administered in flexible dose.
RESULTS
In frequency of nocturia, single administration of the anticholonergics improved significantly at post-treatment 1st, 3rd and 6th month compared to pre-treatment level. The more severe the frequency of the nocturia was, the more it was improved by medication but there is no significant difference. Daytime frequency is significantly improved 3 month and 6 month after medication. In urgency and urge incontinence, the significant improvement was also observed at post-treatment 3rd month and 6th month. The significant differences between pre-treatment and post-treatment were not demonstrated in maximal flow rate and post-void residual urine. Dry mouth was the most common side effect but mild and tolerable.
CONCLUSION
The single administration of the trospium chloride demonstrated a clinically significant improvement in nocturia as well as symptoms of the overactive bladder and did not affect negatively on bladder contractility.
Keywords: Nocturia; Treatment; Anticholinergics
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Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
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