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Int Neurourol J > Volume 20(2); 2016 > Article
Wu, Xing, Wen, Li, Xie, Feng, Shang, Li, Feng, Wang, Zhai, He, Chen, Liu, and Wen: Prevalence of Spina Bifida Occulta and Its Relationship With Overactive Bladder in Middle-Aged and Elderly Chinese People



To investigate the prevalence of spina bifida occulta (SBO) and its relationship with the presence of overactive bladder (OAB) in middle-aged and elderly people in China.


A cross-sectional community-based survey was carried out at 7 communities in Zhengzhou City, China from December 15, 2013 to June 10, 2014, where residents aged over 40 years were randomly selected to participate. All of the participants underwent lumbosacral radiographic analysis and relevant laboratory tests. A questionnaire including basic information, past medical history and present illness, and the OAB symptom score was filled out by all participants. Chi-square tests and logistic regression were used for data analysis with a P-value of <0.05 denoting statistical significance.


A total of 1,061 subjects were qualified for the final statistical analysis (58.8±11.7 years; male, 471 [44.4%]; female, 590 [55.6%]). The overall prevalence of SBO was 15.1% (160 of 1,061): 18.3% (86 of 471) in men and 12.5% (74 of 590) in women. Among these subjects, 13.7% (145 of 1,061) had OAB: 13.2% (62 of 471) in men and 14.1% (83 of 590) in women. The results of logistic regression showed that age, SBO, history of cerebral infarction (HCI), and constipation were risk factors for OAB (P<0.05), while sex, history of childhood enuresis (HCE), body mass index (BMI), and diabetes mellitus (DM) were not (P>0.05). In men, age, SBO, and constipation were risk factors for OAB (P<0.05), while HCE, BMI, DM, HCI, and benign prostate hyperplasia were not (P>0.05). In women, age, SBO, and HCI were risk factors for OAB (P<0.05), while HCE, BMI, DM, vaginal delivery, and constipation were not (P>0.05).


The prevalence of SBO is high and it is related to OAB in middle-aged and elderly people in China.



    Spina bifida occulta (SBO) is a subtle form of dysraphism with one or more split spinous processes and widened interpedicular distances on plain radiography [1]. These major pathologies combined with other abnormalities, though relatively uncommon, form the so-called tethered cord syndrome (TCS). These abnormalities include cutaneous changes (midline lumbosacral cutaneous hemangiomas, lumbosacral hypertrichosis, lumbosacral dermal sinus, and skin appendages), neurological and orthopedic changes (sensory loss and structural deformities of the feet, limb-length abnormalities, muscular atrophy of the legs, gait disturbance, limb pain, and scoliosis), bladder/bowel dysfunction (repeated urinary tract infection [UTI], voiding dysfunction, bowel incontinence), vertebral anomalies (bifid vertebrae, laminar defects, hemivertebrae), and anorectal and urogenital malformations (imperforate anus, renal dysplasia, bladder exstrophy) [1-3].
    The majority of subjects with SBO of the lower spine and sacrum do not have clinical manifestations such as neurological abnormalities and cutaneous/subcutaneous malformations. However, Galloway and Tainsh [4] demonstrated an increased prevalence of SBO in a small group of adults with lower urinary tract problems. Furthermore, Fidas et al. [5] revealed a significant increase in the prevalence of SBO at the levels of S1 and S2 in patients with urological symptoms, including urgency and instability in men and stress incontinence and urgency in women. However, both studies had, to some extent, design issues. One did not perform statistical analysis and the other did not exclude confounding factors such as benign prostate hyperplasia (BPH), diabetes, and UTIs. Clearly, more comprehensive studies are warranted to delineate the relationship between SBO and lower urinary tract symptoms (LUTS). Using multiple methodologies, our current study aimed to establish the prevalence of SBO and its relationship with OAB through screening of middle-aged and elderly Chinese people.


    We randomly selected 7 communities in Zhengzhou City from December 15, 2013 to June 10, 2014 and assigned a serial number to every member of the community over 40 years old. We then used a random number table to randomly choose 170 persons in each community. Finally, 1,190 samples were selected and 1,061 people participated in this survey after applying the exclusion criteria. The exclusion criteria included pregnancy; seniors lacking communication capability due to dementia; paraplegics; a history of spinal disease; past surgeries on the prostate, urethra, or bladder; obscure digital radiography because of intestinal gas; a history of diuretics therapy; inconsistent diagnoses between the 2 radiologists.
    All of the participants underwent lumbosacral radiography, routine urine tests, an oral glucose tolerance test (OGTT), and ultrasonography of the urinary system to establish the diagnosis of SBO and to identify cases of UTI, diabetes mellitus (DM), and BPH to exclude any potential confounding factors. A questionnaire including basic information such as past medical history, present illness, and the OAB symptom score (OABSS) was filled out by each participant.
    The diagnostic criteria of OAB were established as an urgency score of OABSS≥2 and a total score≥3 [6]. DM was defined as follows: (1) Previously diagnosed with DM; (2) If the fasting blood glucose was above 7.0 mmol/L, an OGTT was administered and 2-hour postprandial blood glucose >11.1 mmol/L was diagnosed as diabetes. The prostate volume was estimated as transverse diameter×anteroposterior diameter×length×0.52, and BPH was diagnosed if the prostate volume was >25 cm3.
    Plain spinal and sacral radiographs obtained from all subjects were assessed by 2 senior radiologists for the presence or absence of fusion of the posterior elements of the lumbar and/or sacral vertebrae above S3 [7]. No evident abnormalities were found during physical examinations.
    IBM SPSS Statistics ver. 21.0 (IBM Co., Armonk, NY, USA) was used for data analysis. Chi-square tests were used to determine the differences of prevalence between sex, age groups, and people with SBO or OAB. A stepwise multivariable logistic regression analysis was used to control for potential confounding variables and to determine risk factors associated with OAB. A P-value of <0.05 was denoted as statistically significant.


    Altogether 1,061 subjects were qualified for the final statistical analysis (58.8±11.7 years; 471 men and 590 women). The overall prevalence of SBO in men was 18.3% (86 of 471) and in women, 12.5% (74 of 590). The prevalence of SBO was significantly higher in men than in women (P<0.05). To determine the role of aging in the formation of SBO, the patients were divided into the following groups: 40–49, 50–59, 60–69, 70–79, and ≥80 years. The SBO prevalence of total cases and by sex in each age group is shown in Table 1. No significant difference of SBO prevalence was found among the different age groups (P> 0.05) in either sex. S1 was identified as the most frequent location of SBO, accounting for 79.4% (127 of 160) of cases, while the prevalences of SBO at S2, L5–S1, S1–S2, and L5 were 6.8% (11 of 160), 6.3% (10 of 160), 4.4% (7 of 160), and 3.1% (5 of 160), respectively.
    A total of 145 cases with OAB were identified, an overall prevalence of 13.7%. No significant difference in the prevalence was found between men (13.2%, 62 of 471) and women (14.1%, 83 of 590), P>0.05. Of note, the prevalence of OAB increased with age: 6.6% (15 of 227), 9.1% (34 of 374), 14.8% (34 of 229), 24.3% (46 of 189), and 38.1% (16 of 42) for the groups aged 40–49, 50–59, 60–69, 70–79, and ≥80 years old, respectively. The prevalence of OAB was significantly lower in the 50–59 age group subjects than those in the 60–69 and 70–79 groups (P<0.05), while no difference was detected among the other age groups. Altogether 54 OAB cases also had SBO and the prevalence of OAB in the subjects with SBO was 33.8% (54 of 160), which was significantly higher than for those without SBO (10.1%, 91 of 901; P<0.0001). The prevalence of SBO in the subjects with OAB was 37.2% (54 of 145), which was significantly higher than in those without OAB (11.6%, 106 of 916; P<0.0001).
    When we investigated the relationship between different locations of SBO and OAB severity, we found no significant difference of OAB prevalence among the different locations of SBO (P>0.05). However, there were also no significant differences among groups S2 and L5 and the no-SBO group (P > 0.05), which may be due to the limited number of persons in groups L5 and S2 (Table 2).
    Among the 1,061 subjects, there were 40 with a history of history of cerebral infarction (HCI), 91 with history of childhood enuresis (HCE), 95 with constipation, 99 with DM, 271 with BPH (81 with no symptoms), and 543 with vaginal delivery.
    Logistic regression analysis demonstrated that in the general population, age, SBO, HCI, and constipation were risk factors for OAB (P <0.05), while sex, HCE, BMI, and DM were not (P>0.05) (Table 3). In men, age, SBO, and constipation were risk factors for OAB (P<0.05), while HCE, BMI, DM, HCI, and BPH were not (P>0.05) (Table 4). In women, age, SBO, and HCI (P<0.05) were risk factors for OAB, but HCE, BMI, DM, constipation, and vaginal delivery were not (P>0.05) (Table 5).
    Since previous studies have reported that BPH is one of the risk factors for OAB, which is different from our conclusion, we also subdivided the cases with BPH using the severity score from the International Prostate Symptom Score (IPSS Form) to identify whether moderate or severe BPH was associated with OAB. There were 271 men with BPH (151, 94, and 26 men had an IPSS ≤7, ≥8 but ≤19, and ≥20 but ≤35, respectively). The incidence of OAB in men with mild BPH, moderate or severe BPH, and men without BPH was 5.3% (8 of 151), 35.8% (43 of 120), and 5.5% (11 of 200), respectively. Although the prevalence of BPH was not related to OAB, the incidence of OAB in moderate or severe BPH was significantly higher than in men with mild BPH or without BPH.


    SBO was first described and treated in 1891 by Jones, and surgery was suggested as a treatment by Brickner in 1918 [2]. Subsequently, increasingly more articles about the classification of and clinical manifestations of SBO were reported by neurosurgeons and urologists. SBO includes a large number of malformations including meningocele, meningocele manque, spinal lipomas, neurenteric cysts, split cord malformation, fatty filum terminale, terminal (lower one-third of the spinal cord) syrinx and dermal sinus tract, and simple nonfusion of the vertebral arches [8]. Generally, simple nonfusion of the vertebral arches accounts for the majority of SBO cases. Different subcategories display diverse clinical features. Because of the different characteristics and different locations of spinal cord lesions, SBO can affect multiple systems. However, it can also manifest as a single symptom such as nocturnal enuresis, repeated UTIs, or voiding dysfunction [9].
    SBO is a relatively common anatomical variant that in one study was identified in 22% of the population (patients presenting to an emergency treatment service) ranging in age from 2 months to 98 years [10]. Other reports of its prevalence vary from 10% to 58% [7,11,12]. These discrepancies may result from degenerative changes in seniors during the aging process. Differences between the races and sexes may also play a role.
    Radiographic studies by Sutow and Pryde [12] for the first time demonstrated significant differences of the SBO prevalences among different age groups and that the prevalence decreased with age. Fidas et al. [7] also reviewed plain radiographs of the lumbosacral spine of 2,707 normal adult volunteers and they found that the prevalences of SBO in men, women, and all adults were 30%, 17%, and 23%, respectively. While the prevalence is almost double in men compared to women younger than 60 years, it becomes almost equal when the subjects are over 60 years of age [7]. The higher SBO prevalence in younger adults may be attributed to new bone formation or calcification as a result of degenerative processes [13]. A meta-analysis suggests that the most accurate estimate of the SBO incidence is 17%, with the lumbosacral spine being the most frequently affected site. Laminar defects in the cervicothoracic spine are more common in patients of African descent compared to other races [14], suggesting race is a factor contributing to different prevalences of SBO.
    We for the first time investigated the prevalence and the lesion sites of SBO among the Chinese people. Working with professional statisticians, we tried to design our study to make the results more reliable. We performed a cross-sectional study to evaluate the prevalence of SBO in normal adults. By doing so, we expected to exclude many confounding factors that arise in retrospective studies, such as spinal diseases [7].
    Our cross-sectional, cross-sectional survey was carried out in a randomized, double-blind way in combination with a self-administered questionnaire for the subjects aged over 40 years. All of the subjects were subjected to radiographic and other examinations in our hospital. Our results showed that the overall prevalence of SBO among the Chinese aged over 40 years was 15.1% (160 of 1,061), and its prevalence in men was 18.3% and 12.5% in women. The prevalence of SBO was significantly higher among men than in women (P<0.05). Consistent with the meta-analysis mentioned above regarding the impact of race on SBO formation, one age-matched (over 40 years) study revealed a significantly higher prevalence of SBO in a Chinese population than in a British one (15.1% vs. 9.8%, P<0.05) [10].
    The studies exploring the relationship between SBO and spinal cord abnormalities have generated inconsistent results, and the importance of radiographic SBO in patients with LUTS remains largely unknown. While some scientists suggest that children with SBO are more vulnerable to LUTS, others think that SBO may be a coincidental finding. Its clinical manifestations range from one to multiple symptoms. Reported bladder abnormalities in SBO include a detrusor hyperreflexia during filling in 42%, low compliance detrusor in 67%, and impaired bladder sensation in 8%. Urethral abnormalities in SBO included detrusor/sphincter dyssynergia in 27%, low pure max in 17%, absent bulbocavernosus reflex in 56%, and absent anal reflex in 57% [9]. In contrast, Samuel and Boddy [1] evaluated 158 children with LUTS, including 58 cases with SBO (36%), and they concluded that SBO was probably a coincidental finding and its true significance in children with LUTS could not be established. In addition, Kumar et al. [15] reported that there was no significant difference in the incidence of SBO between children with or without nocturnal enuresis. Notably, most studies, which generated inconsistent data regarding the relationship between radiographic SBO and urinary voiding problems, were done in children. We thus decided to perform a cross-sectional study in middle-aged and elderly people in our city using a randomized, double-blind design and we believed that our results were reliable and clinically relevant because of fewer confounding factors in our study population.
    Overactive bladder (OAB) syndrome is a common LUTS afflicting millions of people worldwide. The prevalence of OAB is between 3% and 43% [16]. In 2002, the International Continence Society revised the terminology to define OAB as: urgency, with or without urge incontinence, usually with frequency and nocturia, which can be described as the OAB syndrome, urge syndrome, or urgency-frequency syndrome. These terms can be used after excluding infection or obvious pathology [17]. Multiple risk factors may affect the occurrence of OAB, such as age, diabetes, UTIs, childhood nocturnal enuresis, constipation, lack of mobility, cognitive impairment, drug therapy (e.g., diuretics), BMI >30 kg/m2, and vaginal delivery [18-21]. We therefore excluded subjects with some conditions including those with UTIs, lack of mobility, cognitive impairment, and diuretics therapy. Our results indicated that age, SBO, HCI, and constipation were risk factors for OAB among general subjects, as well as age, SBO, and constipation in men and age, SBO, and HCI in women (P<0.05).
    While age is a well-established risk factor, the role of HCE, obesity, constipation, DM, and vaginal delivery in OAB remain elusive. Our study showed that constipation had a different impact on men and women for OAB, suggesting a role of anatomical differences in the pelvic cavity. Because the rectum is adjacent to the bladder in men, constipation with rectal distension puts direct pressure on the posterior bladder wall causing bladder overactivity, trigonal irritation, post bladder wall invagination, bladder and urethral obstruction, or distension [22]. In contrast, as the bladder and rectum are separated by the vagina and uterus in women, a dilated rectum does not have a direct impact on the bladder.
    A plausible explanation for the different effect of HCI on OAB in men and women might be due to the different diagnostic criteria for cerebral infarction in different hospitals (the data about HCI were obtained orally from subjects who obtained their diagnoses of cerebral infarction from different doctors and hospitals).
    Somewhat surprisingly, our results indicated that BPH was not a risk factor for OAB, which was not consistent with some previous observations. We reasoned that our cross-sectional study design did make a difference in findings as compared to retrospective investigations. Our screening demonstrated that many men with BPH did not have any urinary symptoms, suggesting asymptomatic BPH did not affect bladder function and thus was not a risk factor for OAB. This possibility was confirmed by the relationship between the BPH severity score and the existence of OAB.
    Little information is available regarding SBO being a potential risk factor for OAB. Our logistic analysis of the relationship between SBO and OAB showed an OR value of 4.91 with the 95% confidence interval being 3.2–7.53. The risk of suffering OAB in persons with SBO was 5 times higher than for people without SBO, which was consistent with Fidas’s observation [5]. An urodynamic study of 43 patients with SBO showed phasic detrusor overactivity in 72% cases [4]. Similarly, Guerra et al. [23] demonstrated that detrusor overactivity was present in 71% (17 of 24) of children with SBO [23]. Thus, it is reasonable to reach the conclusion that SBO is a real deformity, instead of a normal anatomical variant, and it plays a role in OAB in adults.
    The precise mechanism responsible for the formation of OAB remains largely unknown. An important reason is that OAB is a diagnosis based on clinical manifestations and patients complaints, which makes it difficult to establish a reliable animal model to test different hypotheses. Three main theories have been proposed regarding the cause of OAB and detrusor overactivity, namely, the myogenic or muscle related theory [24], the autonomous bladder theory [25], and the neurogenic or nerve related theory [26]. SBO leading to OAB may be related to the third theory—the nerve related theory, implying that damage to central inhibitory pathways in the brain or spinal cord or sensitization of peripheral afferent terminals in the bladder can unmask primitive voiding reflexes that trigger detrusor overactivity.
    Several hypotheses have been proposed to explain the role of SBO in OAB. The first hypothesis is that those outcomes were secondary to a reduction in oxygen metabolism in the mitochondria of the neuronal cells of the tethered lumbosacral cord [27]. The traction on the cord between 2 fixation points leads to stretching, kinking, and distortion of the arterioles, venules, and capillaries to the spinal cord, resulting in intermittent neuronal hypoxia and accumulated damage. Increased growth has been hypothesized to cause neurological deterioration. Metabolic injury occurs preferentially to spinal neurons with higher oxygen requirements, such as interneuronal axon connections that lead to the clinical manifestation of bladder dysfunction. In contrast, the long neuronal tracts affecting muscular movements are less susceptible to early hypoxic injury, which may explain the early, often isolated appearance of bladder dysfunction and later appearance of lower limb findings in the TCS [28]. Detrusor hyperreflexia is the most common urodynamic finding, which is in contrast to other types of bladder dysfunction.
    A second hypothesis speculates that SBO related to detrusor overactivity is associated with the emergence of a capsaicin-sensitive C-fiber-mediated spinal micturition reflex caused by a reorganization of synaptic connections in the spinal cord. These C-fibers that are usually silent during a normal state of bladder filling become active during a pathological state and can fire even at low pressures [29]. During spinal cord injury, the bladder afferents, which normally are unresponsive to low intravesical pressures, become more mechanosensitive, leading to the development of detrusor overactivity. The mechanism underlying the increased mechanosensitivity of C-fibers may be plasticity of the dorsal root ganglion cells supplying the bladder as evidenced by enlargement of these cells and increased electrical excitability [29].
    The third hypothesis suggests that dysplasia of the spinal cord may interfere with nerve conduction by a gradual process. It is postulated that the extrinsic anomalies strangulate or limit movement of nerve structures within the theca and fat deposits may cause pressure on spinal structures [14].
    Although the mechanism for SBO mediated OAB is not fully understood, accumulating evidence suggests that clinical symptoms are caused by SBO combined with TCS or other spinal cord abnormalities.
    A critical question remains unanswered: how can a congenital condition have its first clinical manifestation only at an adult age? It is thought that with subtle tethering, SBO will remain asymptomatic during childhood, and cumulative micro damage from repeated insults throughout life results in adult onset TCS [30]. Therefore, an otherwise asymptomatic, mild tethering may become symptomatic over the years. In our opinion, there may be no spinal cord tethering in children with SBO when they are born. However, compared with those without SBO, they are more vulnerable to spinal cord injury during the following conditions: repeated spinal flexion, pregnancy and parturition, long-term heavy lifting, and intense activities.
    We acknowledge the limitations of this study: the lack of spinal magnetic resonance imaging (MRI) and urodynamic studies because of insufficient financial support. However, we will perform these examinations in our follow-up studies, although a previous report indicates that patients with SBO and LUTS may not need to undergo spinal MRI [31].
    In conclusion, the prevalence of SBO among the Chinese is significantly higher than that among the English, indicating that SBO might be region- and race-dependent. In addition, the prevalence of SBO is significantly higher among men than women, presumably reflecting genetic, ethnic, and environmental factors, which are at present poorly understood. Furthermore, SBO could gradually lead to dysfunction of spinal nerves and LUTS, such as OAB; therefore, rather than a normal variation as suggested by other researchers, SBO is a real deformity and a novel risk factor for OAB.


    We thank radiologists Qiang Wu, Jianbo Gao, and the members of the Center of Health Examination in the First Affiliated Hospital of Zhengzhou University for offering their important help.


    Fund/Grant Support
    This study was supported by the National Science Foundation of China (81373869) and the Scientific Research Foundation for the Doctoral Program of Zhengzhou University.
    Research Ethics
    This research has been approved by the Medical Research Ethics Committee of The First Affiliated Hospital of Zhengzhou University, and the authorization number is Scientific Research 49th, 2013.
    Conflict of Interest
    No potential conflict of interest relevant to this article was reported.


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    Table 1.
    The incidence of SBO in total cases, male and females by decades
    Age (yr) Total (%) Male (%) Female (%)
    40–49 18.9 (43/227) 22.7 (30/132) 13.7 (13/95)
    50–59 13.4 (50/374) 14.2 (21/148) 12.8 (29/226)
    60–69 12.7 (29/229) 18.1 (15/83) 9.6 (14/146)
    70–79 15.9 (30/189) 18.1 (15/83) 14.2 (15/106)
    ≥ 80 19.0 (8/42) 20.0 (5/25) 17.7 (3/17)

    SBO, spina bifida occulta.

    Table 2.
    The information of the relationship among different location of SBO and the OAB severity
    Location of SBO No. of SBO No. of OAB OAB in each group (%) Moderate or severe OAB (OABSS ≥ 6), n (%)
    S1 127 44 34.6 28 (22.0)
    S2 11 2 18.2 2 (18.2)
    L5 5 2 40.0 1 (20.0)
    L5+S1/S1+S2 17 6 35.3 5 (29.4)
    No. of SBO - 91 10.1 (91/901) 72 (8.0)

    SBO, spina bifida occulta; OAB, overactive bladder; OABSS, OAB symptom score.

    Table 3.
    The results of logistic regression in total samples
    Factor β SE Wald P-value OR 95% CI
    Age 0.05364 0.00831 6.456 < 0.001 1.06 1.04–1.07
    Sex 0.18610 0.19845 0.938 0.348 1.20 0.82–1.78
    SBO 1.59191 0.21806 7.300 < 0.001 4.91 3.2–7.53
    HCE 0.29635 0.32645 0.908 0.364 1.34 0.71–2.55
    BMI 0.07847 0.27871 0.282 0.778 1.08 0.63–1.87
    DM –0.58676 0.33779 –1.737 0.082 0.56 0.29–1.08
    HCI 0.98403 0.37892 2.597 0.009 2.68 1.27–5.62
    Constipation 0.70356 0.70356 2.460 0.014 2.02 1.15–3.54

    SE, standard error; OR, odds ratio; CI, confidence interval; SBO, spina bifida occulta; HCE, history of childhood enuresis; BMI, body mass index; DM, diabetes mellitus; HCI, history of cerebral infarction.

    Table 4.
    The results of logistic regression in males
    Factor β SE Wald P-value OR 95% CI
    Age 0.05022 0.01304 3.850 < 0.001 1.05 1.02–1.08
    SBO 1.33603 0.33243 4.019 < 0.001 3.80 1.98–7.30
    HCE 0.21904 0.39718 0.551 0.581 1.24 0.57–2.71
    BMI 0.04912 0.51523 0.168 0.619 0.70 0.51–1.47
    DM –0.98762 0.53614 –1.842 0.065 0.37 0.13–1.07
    HCI –0.19162 0.69159 –0.277 0.782 0.83 0.21–3.20
    Constipation 0.99504 0.45723 2.176 0.030 2.70 1.10–6.63
    BPH 0.5711 0.36936 1.546 0.122 1.77 0.86–3.65

    SE, standard error; OR, odds ratio; CI, confidence interval; SBO, spina bifida occulta; HCE, history of childhood enuresis; BMI, body mass index; DM, diabetes mellitus; HCI, history of cerebral infarction; BPH, benign prostate hyperplasia.

    Table 5.
    The results of logistic regression in females
    Factor β SE Wald P-value OR 95% CI
    Age 0.05007 0.01268 3.950 < 0.001 1.05 1.03–1.08
    SBO 1.94203 0.29864 6.503 < 0.001 6.97 3.88–12.52
    HCE 0.50058 0.56813 0.881 0.378 1.65 0.54–5.02
    BMI 0.08467 0.48712 0.236 0.425 1.37 0.74–1.92
    DM 0.40827 0.46052 0.887 0.375 0.66 0.27–1.64
    HCI 1.68404 0.48866 3.446 < 0.001 5.39 2.07–14.04
    Constipation 0.50077 0.38834 1.290 0.197 2.70 1.10–6.63
    VD 0.07382 0.58035 0.127 0.899 1.65 0.77–3.53

    SE, standard error; OR, odds ratio; CI, confidence interval; SBO, spina bifida occulta; HCE, history of childhood enuresis; BMI, body mass index; DM, diabetes mellitus; HCI, history of cerebral infarction; VD, vaginal delivery.

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