INJ Search


Int Neurourol J > Volume 24(3); 2020 > Article
Nikkola, Holm, Seppänen, Joutsi, Rauhala, and Kaipia: Reply to Commentary on “Repetitive Transcranial Magnetic Stimulation for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Pilot Study”
We gladly welcome the discussion in the commentary [1]. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) patients indeed lack novel treatment options and unfortunately research interest on treatment-resistant pain associated with long-lasting CP/CPPS has been scarce. Since CP/CPPS would be a new indication for repetitive transcranial magnetic stimulation (rTMS), the aim of this feasibility study was to assess if rTMS would have any effect on pain in CP/CPPS in order to give support for future randomized controlled trials.
As discussed in the article [2] and in the commentary, the findings fit the typical response profile of rTMS. In clinical use on depression and pain indications, our institutional protocol is modified from study by Hodaj et al. [3]. It consists of intensive period of 10 sessions during 2 weeks followed by 8 maintenance sessions over the first 2 months: 2 weekly sessions for the first 2 weeks, 1 weekly session for the next 2 weeks and 1 session in 2 weeks then after. After that, the interval of maintenance treatment can be lengthened. In pain indications 1–2 sessions per month is typical in patients receiving positive response and undergoing maintenance treatment.
The current recommendations for rTMS state, that there still is not unequivocal maintenance treatment algorithm available [4]. The present study encourages future research on rTMS for CP/CPPS and show that at least moderate treatment response can be reached even with short treatment and without maintenance. We encourage future randomized controlled trials to study also the role of maintenance sessions.


Conflict of Interest
No potential conflict of interest relevant to this article was reported.


1. Shin YS, Lee KS, Kam SC. Commentary on “Repetitive transcranial magnetic stimulation for chronic prostatitis/chronic pelvic pain syndrome: a prospective pilot study”. Int Neurourol J 2020;24:296. crossref
2. Nikkola J, Holm A, Seppänen M, Joutsi T, Rauhala E, Kaipia A. Repetitive transcranial magnetic stimulation for chronic prostatitis/chronic pelvic pain syndrome: a prospective pilot study. Int Neurourol J 2020;24:144-9. PMID: 32615676
crossref pmid pmc pdf
3. Hodaj H, Alibeu JP, Payen JF, Lefaucheur JP. Treatment of chronic facial pain including cluster headache by repetitive transcranial magnetic stimulation of the motor cortex with maintenance sessions: a naturalistic study. Brain Stimul 2015;8:801-7. PMID: 25979838
crossref pmid
4. Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014–2018). Clin Neurophysiol 2020;131:474-528. PMID: 31901449
crossref pmid
Share :
Facebook Twitter Linked In Google+
METRICS Graph View
  • 0 Crossref
  • 0 Scopus
  • 852 View
  • 28 Download
We recommend

Article Category

Browse all articles >


Browse all articles >


Browse all articles >


Browse all articles >


Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
Editorial Office
Department of Urology, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine,
29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea
Tel: +82-2-2001-2237     Fax: +82-2-2001-2247    E-mail:

Copyright © 2021 by Korean Continence Society.

Developed in M2PI

Close layer
prev next