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Int Neurourol J > Accepted Articles
DOI: https://doi.org/10.5213/inj.2040464.232    [Accepted]
Correlation Between Nitric Oxide and Urodynamics in Men With Bladder Outlet Obstruction
Kang Jun Cho1, Jun Sung Koh1, Jin Bong Choi1, Sang Hi Park2, Weon Sun Lee2, Joon Chul Kim1
1Department of Urology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea
2Institute of Clinical Medicine Research, The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon, Korea
Correspondence  Joon Chul Kim ,Email: kjc@catholic.ac.kr
Submitted: 7 December 2020;  Accepted after revision: 16 February 2021.
ABSTRACT
Purpose
To investigate the correlation between nitric oxide (NO) and urodynamics in men with bladder outlet obstruction (BOO) by analyzing nitric oxide synthase (NOS) in the urothelium.
Methods
We prospectively enrolled 25 men who planned to undergo surgical treatment for benign prostatic obstruction and identified as BOO in the preoperative urodynamics. Bladder tissue was taken during surgical prostate resection. Expressions of endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS) in the urothelium were analyzed, and their correlation with urodynamic parameters was also assessed in all patients. We also compared the expressions of eNOS, iNOS, and nNOS between BOO with detrusor underactivity (DU) group and BOO without DU group.
Results
In all patients, the level of eNOS positively correlated with maximal flow rate and with maximum cystometric capacity (MCC). The level of iNOS positively correlated with MCC. nNOS levels were positively correlated with detrusor pressure at maximal flow and with bladder contractility index in all patients. The level of eNOS, iNOS, and nNOS did not significantly differ between BOO without DU group and BOO with DU group.
Conclusions
This study suggests that NO was correlated with bladder dysfunction in men with BOO. Particularly, nNOS may reflect the change in detrusor function.
Keywords: Nitric oxide synthase; Prostatic hyperplasia; Urinary bladder outlet obstruction; Urodynamics
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Official Journal of Korean Continence Society & ESSIC (International Society for the Study of BPS) & Korean Society of Urological Research & The Korean Children’s Continence and Enuresis Society & The Korean Association of Urogenital Tract Infection and Inflammation & Korean Society of Geriatric Urological Care
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